Targeting M1/M2 Macrophage Polarization Balance by Traditional Chinese Medicine in Treatment of Bronchial Asthma： A Review
10.13422/j.cnki.syfjx.20250111
- VernacularTitle:中医药靶向M1/M2巨噬细胞极化平衡治疗支气管哮喘研究进展
- Author:
Jie LIU
1
;
Yasheng DENG
2
;
Weiping YIN
1
;
Lei XIONG
1
;
Na WANG
3
Author Information
1. The First Affiliated Hospital of Yunnan University of Chinese Medicine， Kunming 650500， China
2. Guangxi University of Traditional Chinese Medicine， Nanning 530000， China
3. Children's Hospital of Fudan University， Shanghai 201102， China
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
macrophage polarization;
traditional Chinese medicine;
active ingredient
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(10):308-317
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma （BA） is a common chronic inflammatory airway disease characterized by airway hyperresponsiveness and reversible airflow limitation. Lung macrophages （LMs）， as important effector cells of the innate immune system， play an important role in recognizing and engulfing pathogens， clearing harmful particles， and regulating immune responses. LMs can be polarized to M1 （pro-inflammatory） or M2 （anti-inflammatory） in different immune environments and participate in promoting or inhibiting inflammatory response， as well as lung parenchyma injury and repair （airway remodeling）， playing a key role in the BA occurrence and development. Regulating the polarization balance of macrophages can not only inhibit the inflammatory response in the airway and reduce airway hyperresponsiveness， but also improve airway remodeling and immune regulation， reduce airway mucus secretion， and alleviate the clinical BA symptoms. Traditional Chinese medicine and its active ingredients， especially polysaccharides and saponins， can regulate the polarization balance of M1/M2 macrophages. Traditional Chinese medicine compounds can balance the secretion of anti-inflammatory and pro-inflammatory factors by staging treatment and targeting the polarization state of M1/M2 macrophages， inhibit inflammatory response in the airway， reduce airway remodeling， and improve the BA symptoms. This paper summarized the research progress on the regulation of M1/M2 macrophage polarization by traditional Chinese medicine and its active ingredients， aiming to provide scientific evidence for the precise targeted therapy of BA.
