Research progress on high adaptability of pathogenic fungi to drugs
10.12206/j.issn.2097-2024.202510030
- VernacularTitle:病原真菌对药物高适应性的研究进展
- Author:
Yuru LIN
1
;
Qiaoling HU
1
;
Xinrong WANG
2
;
Renyi LU
2
;
Yan WANG
3
;
Li CHEN
4
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. School of Pharmacy, Naval Medical University, Shanghai 200433, China;Innovation Center for Medical Basic Research on Fungal Infectious Diseases, Ministry of Education, Shanghai 200433, China.
4. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
- Publication Type:Reviews
- Keywords:
pathogenic fungi;
adaptability;
resistance;
tolerance;
persistence
- From:
Journal of Pharmaceutical Practice and Service
2026;44(4):178-184
- CountryChina
- Language:Chinese
-
Abstract:
Fungal infections have emerged as a critical public health issue endangering human health. However, the existing arsenal of antifungal agents is limited in diversity and is commonly plagued by drawbacks including narrow antimicrobial spectrums and the frequent emergence of drug resistance, which severely compromises the efficacy of clinical treatments. Pathogenic fungi can develop extensive adaptability to currently available drugs through multiple mechanisms, which are mainly manifested in three aspects: drug resistance, tolerance and persistence. The molecular mechanisms and regulatory pathways underlying drug resistance, tolerance and persistence in pathogenic fungi were systematically summarized in this review, and the counteractive strategies such as combination therapy and the development of novel antifungal agents were further discussed, which aimed to provide theoretical basis and practical reference for the precision treatment of fungal infections.
