Research progress on the mechanism of anti-hepatic fibrosis by alkaloids in traditional Chinese medicine
10.12206/j.issn.2097-2024.202504127
- VernacularTitle:中药生物碱抗肝纤维化作用的研究进展
- Author:
Danping FANG
1
;
Fangyuan XIE
2
;
Yan WANG
3
;
Weiheng XU
4
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
2. The Third Affiliated Hospital of Naval Medical University, Shanghai 200082, China.
3. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
4. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
hepatic fibrosis;
traditional Chinese medicine;
alkaloids
- From:
Journal of Pharmaceutical Practice and Service
2026;44(4):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a pathological repair response of the liver to various chronic injuries, commonly seen in chronic liver diseases such as viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, etc. Hepatic fibrosis is a necessary stage for the development of chronic liver disease into cirrhosis or even hepatocellular carcinoma. Reversing or delaying the progression of hepatic fibrosis is crucial for the treatment of chronic liver disease, but there are currently no safe and effective therapeutic drugs in clinical practice. In recent years, research has found that many alkaloids in traditional Chinese medicine have anti-fibrotic activity, and their mechanisms involved multiple aspects such as cell autophagy, antioxidation, and anti-inflammation. The anti-fibrotic effects and mechanisms of alkaloids from traditional Chinese medicine were reviewed, which could provide reference for the application of alkaloids in the prevention and treatment of hepatic fibrosis.
