Advances in reno-protective effects of traditional Chinese medicine in the treatment of hyperuricemia
10.12206/j.issn.2097-2024.202507029
- VernacularTitle:中药治疗高尿酸血症的肾保护作用研究进展
- Author:
Xiaoting ZHOU
1
;
Yu DUAN
2
;
Xingyuan LI
2
;
Qin LIU
3
;
Aijun LIU
1
Author Information
1. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;Department of Pharmacy Research, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
2. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
3. Department of Pharmacy Research, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Reviews
- Keywords:
hyperuricemia;
renal injury;
renoprotection;
urate-lowering;
uric acid transporters
- From:
Journal of Pharmaceutical Practice and Service
2026;44(4):167-172
- CountryChina
- Language:Chinese
-
Abstract:
Hyperuricemia （HUA） is a common metabolic disorder characterized by persistently elevated serum uric acid levels, leading to uric acid-related renal injury through complex mechanisms involving inflammation, oxidative stress, and fibrosis. Key traditional Chinese medicine （TCM） formulas （e.g., Simiao Powder, Tongfengning） and individual herbal compounds （alkaloids, flavonoids, polysaccharides） with urate-lowering and renal protective properties were systematically summarized, including their mechanisms of regulating uric acid transporters （organic anion transporter 3, urate anion transporter 1, glucose transporter type 9）, inhibiting inflammatory responses （via NF-κB signaling）, reducing oxidative stress （via mitochondrial pathways and antioxidant enzyme enhancement）, and attenuating renal fibrosis （via PI3K/AKT signaling）. The challenges of current studies mainly focus on unclear mechanisms of action and insufficient clinical research. Future research may further explore TCM resources, clarify dual-action mechanisms of urate reduction and renal protection, and identify new therapeutic strategies for hyperuricemia-related renal injury.
