Comparison of anti-VEGF treatment at different preoperative time points on retinal neovascularization in PDR
10.3980/j.issn.1672-5123.2026.5.21
- VernacularTitle:PDR术前不同时间点抗VEGF治疗对视网膜新生血管的影响比较
- Author:
Ruolan LING
1
;
Xi WANG
1
;
Yue HAN
1
;
Yawen QIN
1
;
Jie ZHONG
1
;
Jie LI
1
Author Information
1. School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, China; Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital;Affiliated Hospital of UESTA, Chengdu 610072, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
proliferative diabetic retinopathy(PDR);
intraoperative fluorescein angiography;
anti-vascular endothelial growth factor(VEGF)therapy;
vitrectomy;
vitreous hemorrhage;
conbercept
- From:
International Eye Science
2026;26(5):856-861
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the optimal timing of preoperative intravitreal anti vascular endothelial growth factor(VEGF)therapy in proliferative diabetic retinopathy(PDR)using intraoperative fluorescein angiography(IOFA).METHODS:A retrospective case series study was conducted on patients who underwent vitrectomy for PDR with vitreous hemorrhage(VH)at Sichuan Provincial People's Hospital from January 2023 to February 2025. Patients were divided into three groups according to the interval between intravitreal conbercept injection and surgery: Group A(3 d before surgery), Group B(7 d before surgery), and Group C(14 d before surgery). IOFA was used to assess the number and size of retinal neovascularization(NV). Additional data were collected including preoperative best corrected visual acuity(BCVA), vitreous hemorrhage grading, operative time, frequency of intraoperative endodiathermy, duration of high perfusion pressure, vitreoretinal adhesion grade, postoperative BCVA, and central macular thickness(CMT). Multidimensional analyses were performed.RESULTS:This study enrolled a total of 91 patients(94 eyes)with PDR accompanied by vitreous hemorrhage. Among them, Group A consisted of 31 patients(31 eyes; 18 males, 13 females; mean age 53.26±12.38 y), Group B consisted of 34 patients(37 eyes; 21 males, 13 females; mean age 51.61±14.16 y), and Group C consisted of 26 patients(26 eyes; 18 males, 8 females; mean age 51.00±12.02 y), with baseline characteristics comparable among the three groups(all P>0.05). Comparative analysis of NV visualized via IOFA revealed that both the number and size of NVs were significantly lower in Groups B and C than in Group A(all P<0.0167), while no statistically significant differences were observed between Groups B and C(both P>0.05). No significant differences were found among the three groups regarding other intraoperative parameters, including operation time, frequency of electrocoagulation application, duration of high perfusion pressure, or grading of vitreoretinal adhesion(all P>0.05).CONCLUSION:IOFA confirms that preoperative anti-VEGF therapy administered 7 or 14 d before surgery is more effective than a 3 d interval in suppressing retinal NV activity in PDR patients.
