Relationship between thyroid hormones and eye diseases
10.3980/j.issn.1672-5123.2026.5.18
- VernacularTitle:甲状腺激素与眼病关系的研究进展
- Author:
Qian LOU
1
;
Longjiao SUN
1
;
Hongsheng BI
1
;
Wenjun JIANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
thyroid hormone;
Graves ophthalmopathy;
retinal diseases;
ocular surface diseases;
myopia
- From:
International Eye Science
2026;26(5):838-843
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormone(TH)is an iodinated derivative of the amino acid tyrosine secreted by the thyroid gland.It promotes glycolipid metabolism and is involved in various physiological and pathological processes by regulating cellular behaviors, such as cell proliferation, differentiation, and apoptosis. Recent studies have found that aberrant expression of TH in the orbit, retina, and sclera, and other ocular tissues can induce abnormal differentiation of orbital soft tissue adipocytes, alteration of retinal oxidative stress, and degradation of posterior scleral extracellular matrix(ECM), which contributes to the pathogenesis of many ophthalmic diseases, including Graves ophthalmopathy(GO), age-related macular degeneration(ARMD), diabetic retinopathy(DR), and myopia. This article reviews the role and mechanism of TH in various ophthalmic diseases, aiming to provide theoretical basis for the prevention and treatment of these ocular disorders.
