Mechanism and therapeutic targets of angiopoietin-like protein 4 in diabetic retinopathy
10.3980/j.issn.1672-5123.2026.5.10
- VernacularTitle:ANGPTL4在糖尿病视网膜病变中的作用机制及治疗靶点研究进展
- Author:
Jingrong FENG
1
;
Yan LI
1
;
Xiaocao REN
1
;
Jixin LI
1
;
Yu MA
1
;
Wenfang ZHANG
1
;
Yi YANG
1
Author Information
1. Department of Ophthalmology,the Second Hospital & Clinical Medical College, Lanzhou University, Lanzhou 730030, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
angiopoietin-like protein 4(ANGPTL4);
diabetic retinopathy;
molecular mechanisms;
therapeutic targeting
- From:
International Eye Science
2026;26(5):785-791
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)remains the leading cause of vision loss in patients with diabetes. Current anti-vascular endothelial growth factor(VEGF)therapies are limited by inadequate response in some patients and the necessity for repeated intravitreal injections, underscoring the urgent need for novel therapeutic targets. Angiopoietin-like protein 4(ANGPTL4), a multifunctional secreted protein, has emerged as a critical regulator in the pathogenesis and progression of DR, positioning it as a promising interventional target. This review systematically elaborates the biological characteristics of ANGPTL4, with a focus on its expression dynamics, molecular mechanisms, and regulatory networks rolesin the development of DR. Furthermore, the prospects of ANGPTL4-targeted therapeutic strategies are discussed, aiming to offer new insights and directions for understanding DR pathogenesis, advancing multi-target drug development, and improving clinical management.
