Chinese Medicine in Regulating Ferroptosis for Treatment of Malignant Tumors： A Review
10.13422/j.cnki.syfjx.20251745
- VernacularTitle:中医药调控铁死亡治疗恶性肿瘤的研究进展
- Author:
Changlin LI
1
;
Guangda ZHENG
2
;
Lu SHANG
1
;
Juanxia REN
1
;
Lingyun WANG
1
;
Dongtao LI
2
;
Haixiao LIU
2
;
Yaohua CHEN
3
;
Guiping YANG
3
;
Yanju BAO
2
Author Information
1. Liaoning University of Traditional Chinese Medicine， Shenyang 110847，China
2. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053，China
3. Xining Hospital of Traditional Chinese Medicine， Xining 810001，China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
malignant tumors;
drug resistance;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(10):355-362
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors are one of the major causes of death in the population. Owing to limited clinical treatments， susceptibility to drug resistance， and generally low cure rates of conventional therapies， new treatment strategies need to be explored. Compared with existing therapies， traditional Chinese medicine （TCM） has unique advantages， such as low side effects， in the treatment of malignant tumors. Ferroptosis is a recently characterized form of regulated cell death associated with iron metabolism imbalance， lipid peroxidation， antioxidant system malfunction and other aspects. Studies have shown that TCM regulates Fe3+， Fe2+， glutathione， glutathione peroxidase 4 and other substances related to ferroptosis， thereby affecting lipid peroxidation and antioxidant processes， and then inducing ferroptosis. Through these mechanisms， TCM plays a key role in inhibiting the growth and spread of tumor cells and is involved in multiple stages of malignant tumor progression. In this study， we systematically retrieved the literature indexed in PbuMed and China National Knowledge Infrastructure （CNKI） with the keywords TCM， ferroptosis， and malignant tumors. We outlined the mechanisms of ferroptosis and its association with malignant tumors， and summarized the research progress on the prevention and treatment of malignant tumors through the modulation of ferroptosis by TCM monomers， single herbs， and compounds. The study aims to provide new perspectives for the prevention and treatment of malignant tumors by TCM.
