Targeted Regulation of Oocyte Quality by Traditional Chinese Medicine Compound Formula： A Review
10.13422/j.cnki.syfjx.20251214
- VernacularTitle:中药复方靶向调控卵母细胞质量的研究进展
- Author:
Zhicheng JIA
1
;
Yong LIU
1
;
Guotao HU
1
;
Ruoxi ZHAO
1
;
Weisen FAN
1
;
Ying GUO
2
;
Ruihua ZHAO
1
Author Information
1. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China
2. Affiliated Hospital of Shandong University of Traditional Chinese Medicine， Jinan 250011， China
- Publication Type:Journal Article
- Keywords:
oocyte;
infertility;
reproductive endocrinology;
traditional Chinese medicine compound formula;
in vitro maturation;
in vitro fertilization-embryo transfer
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(10):328-336
- CountryChina
- Language:Chinese
-
Abstract:
The oocyte， as the origin of life， provides half the chromosomes to the embryo and supplies the proteins， substrates， energy， and other support necessary for embryonic development. It is the decisive factor determining the embryo's developmental potential. Infertility caused by reproductive endocrine diseases targets the oocyte as the final target cell. Improving oocyte quality represents a key and difficult point in the field of modern reproductive medicine. The decline of oocyte quality is related to meiosis abnormalities， DNA damage， mitochondrial dysfunction， oxidative stress， and other mechanisms. For oocyte quality problems， there is no unified international guideline to recommend drugs. Because the drug intervention research on oocytes involves strict clinical ethical restrictions， the current relevant research only stays in the animal and in vitro experimental stage and has not yet been applied to the clinic. Traditional Chinese medicine compound formula has a multi-target and multi-pathway regulation mechanism and is widely used in clinics. More and more research began to pay attention to the potential mechanism of traditional Chinese medicine compound formulas in improving oocyte quality. Traditional Chinese medicine compound formula has the advantages of multi-target and multi-channel synergy as well as better safety， individualization， and conformity to clinical ethics in improving oocyte quality. This article systematically reviewed the research progress on traditional Chinese medicine compound formula interventions for oocyte quality， aiming to summarize existing findings and provide recommendations to improve oocyte quality and optimize the clinical diagnosis and treatment of female infertility within traditional Chinese medicine.
