Construction of A Conceptual Framework for the Integration of Traditional Chinese and Western Medicine in Evolutionary Syndrome Differentiation and Treatment Across Full-cycle of Parkinson's Disease
10.13422/j.cnki.syfjx.20252097
- VernacularTitle:中西医结合辨治帕金森病疾病全周期的理论框架构建
- Author:
Yu WANG
1
;
Jianing MEI
1
;
Hongping ZHAO
1
;
Yunzhe TANG
1
;
Zijun WEI
1
;
Qinliang TAO
1
;
Xueyi HAN
1
;
Jiyuan HU
1
;
Yunyun ZHANG
1
Author Information
1. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine， Shanghai University of Traditional Chinese Medicine，Shanghai 200437，China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
traditional Chinese medicine;
integrative medicine;
full-cycle management;
prosperity-decline of healthy Qi and pathogenic factors;
syndrome differentiation based on visceral theory;
variable syndrome;
critical syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(10):270-279
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease （PD） is a complex neurodegenerative disease involving multiple systems and neurotransmitters. Due to the high clinical heterogeneity of PD，it is urgent to establish a comprehensive and long-term traditional Chinese medicine （TCM） management model. In this paper，the conceptual framework of full-cycle management of PD is preliminarily constructed：based on the evolution of the pathophysiological mechanisms of protein deposition and neurotransmitter disorder in PD，the three-stage syndrome characteristics of the prodromal stage （predominant healthy Qi with subtle pathogenic factors），the early clinical stage （declining healthy Qi with growing pathogenic factors） and the middle and late stages （overwhelming pathogenic factors with deficient healthy Qi） are longitudinally described. Through the syndrome differentiation of visceral manifestations，the etiology and pathogenesis of PD motor and non-motor symptoms were comprehensively analyzed，while the matching treatment methods and prescriptions were inferred，and the modular scheme of the combining main symptoms，accompanying symptoms and secondary symptoms was proposed. The conceptual gap of TCM regarding motor complications （'variable syndrome'） and PD-related hyperpyrexia syndrome （'critical syndrome'） was explained. This framework reflects the characteristics of combination of disease and syndrome and overall constant motion，and provides new theories and research ideas for individualized and whole-process management of PD in TCM.
