Analysis of components absorbed into blood and brain of Lithocarpus litseifolius leaves
- VernacularTitle:木姜叶柯叶的入血及入脑成分分析
- Author:
Huan LIU
1
;
Zirong YI
1
;
Ting HUANG
1
;
Xiuhong LIU
1
;
Yunyao YE
1
;
Yuming MA
1
;
Mengqi HU
1
;
Nan ZHANG
1
;
Wenhao YANG
1
;
Yang LIU
1
;
Guopeng WANG
2
Author Information
1. School of Chinese Materia Medica，Beijing University of Chinese Medicine，Beijing 102488，China
2. Zhongcai Health （Beijing） Biological Technology Development Co. Ltd.，Beijing 101500，China
- Publication Type:Journal Article
- Keywords:
Lithocarpus litseifolius leaves;
components absorbed into blood;
components absorbed into brain;
phloridzin
- From:
China Pharmacy
2026;37(7):889-894
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the prototype components absorbed into blood and brain of Lithocarpus litseifolius leaves， so as to provide a reference for clarifying the pharmacological material basis of its prevention and treatment of central nervous system dis eases. METHODS The ethanol extract of L. litseifolius leaves， as well as the gastric lavage fluid and perfusion solution were prepared. Using rats as subjects， plasma samples of intestinal wall metabolism， intestinal flora metabolism and hepatic metabolism were prepared via in situ intestinal perfusion and closed intestinal loop method； while comprehensive metabolic plasma samples， brain tissue samples， and cerebrospinal fluid samples were collected after intragastric administration. UPLC-HRMS technology was utilized to analyze and identify chemical components and prototype components absorbed into blood and brain of L. litseifolius leaves. RESULTS A total of 66 chemical constituents were identified in L. litseifolius leaves， primarily consisting of flavonoids， organic acids， and others. A total of 16， 13， 11， and 5 prototype components were identified in intestinal wall metabolism， intestinal flora metabolism， hepatic metabolism， and comprehensive metabolic plasma samples， respectively. Additionally， 4 prototype components were detected in brain tissue and 9 in cerebrospinal fluid. Phloridzin， trilobatin， phloretin-2- O -malonyl hexoside， and phloretin were identified as common components across all sample types. CONCLUSIONS Prototype components absorbed into blood and brain of L. litseifolius leaves， such as phloridzin， trilobatin， phloretin， and other components may serve as the pharmacological material basis for their therapeutic effects on central nervous system diseases.
