Investigation and molecular typing of pathogenic bacteria in 32 cases of typhoid and paratyphoid fever in Dalian City
10.3969/j.issn.1006-2483.2026.02.034
- VernacularTitle:大连市32例伤寒和副伤寒病例调查及其病原菌分子分型
- Author:
Bing XIAO
1
;
Jilong JIAO
1
;
Xuesong FAN
1
;
Mingchun LUAN
1
Author Information
1. Microbial Laboratory Department of Dalian Center for Disease Control and Prevention, Dalian, Liaoning 116021, China
- Publication Type:Journal Article
- Keywords:
Typhoid fever;
Paratyphoid fever;
Epidemiological characteristics;
Pulsed field gel electrophoresis;
Molecular typing
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the epidemiological characteristics and molecular subtypes of typhoid and paratyphoid fever in Dalian, and to provide scientific basis for the development of effective prevention and control measures for typhoid and paratyphoid fever. Methods Descriptive epidemiological methods were used to analyze the data of typhoid and paratyphoid reported in Dalian from 2019 to 2023. Pulsed field gel electrophoresis (PFGE) was used for bacterial molecular typing and cluster analysis of the homology of strains. Results A total of 32 cases of typhoid and paratyphoid fever were reported in Dalian from 2019 to 2023. There was no statistically significant difference in the incidence rate between years ( χ2=4.41, P>0.05). There were two peaks in the time distribution. The age of onset was between 30 and 69 years old, and the difference in sex ratio between men and women was statistically significant ( χ2=4.00, P<0.05). The top two occupations with the highest number of cases of typhoid and paratyphoid fever were retired people, housework and unemployed, and the difference in the incidence rate among occupations was not statistically significant (χ2=4.59, P>0.05). PFGE experiment results showed that 32 typhoid and paratyphoid strains isolated from patients can be divided into 25 types. Conclusion The typhoid fever epidemic in Dalian remains stable at a relatively low level from 2019 to 2023. The PFGE banding patterns are relatively scattered, but there are dominant subtypes among them, which may be local epidemic strains.
