Drug resistance and typing characteristics of Acinetobacter baumannii in a tertiary medical institution in Shanghai
10.3969/j.issn.1006-2483.2026.02.033
- VernacularTitle:上海市某三级医疗机构鲍曼不动杆菌耐药及分型特征分析
- Author:
Fengxia QUE
1
;
Guangchao XIONG
1
;
Chunfu LIU
1
;
Guang CAI
1
;
Yunyan YANG
1
;
Yulong YE
1
Author Information
1. Department of Laboratory, Jinshan District Center for Disease Control and Prevention, Jinshan Shanghai 201599, China
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Drug resistance;
MLST;
SNP clustering
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze drug resistance and clustering of environmental and clinical isolates of Acinetobacter baumannii (A. baumannii) in ICU of a medical institution in Shanghai. Methods The isolates of A. baumannii from ICU environments and clinic were used to analyze the contamination and distribution in 2021-2024. Antimicrobial susceptibility testing was carried out with microbroth dilution method. Whole genome sequencing was performed out of strains for MLST typing and SNP clustering. Results The detection rate of contamination in ICU environment was 7.67%, and the most serious contamination was found in pillows, bedding, hospital gowns and other items that patients directly contacted. Clinical isolates were predominantly from sputum specimens. The environmental and clinical isolates had a high level of resistance to third generation cephalosporins, third generation quinolones and carbapenems (more than 85%). Environmental isolates had a low level of resistance to polymyxin B, but none of the clinical isolates were resistant. MLST typing showed that ST2 was the dominant clone (66.67%), and SNP clustering found that isolates from different sources but with the same ST type were clustered together. Conclusion ST2 is the dominant clone of A. baumannii isolates in this medical institution, and there is cross-contamination between different samples. Monitoring of drug resistance and disinfection should be further strengthened to prevent the emergence and spread of pan-resistant or even fully resistant strains.
