Relationship between visceral fat area and glucolipid metabolism indexes and insulin resistance in patients with type 2 diabetes mellitus complicated with obesity
10.3969/j.issn.1006-2483.2026.02.027
- VernacularTitle:内脏脂肪面积与2型糖尿病合并肥胖患者糖脂代谢指标及胰岛素抵抗的关系
- Author:
Chengshan YOU
1
;
Hongfang ZHOU
1
;
Cuiping LIU
1
Author Information
1. Department of Endocrinology and Metabolism, The Second People's Hospital of Yibin City-West China yibin Hospital, Sichuan University, Yibin,, Sichuan 644000, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Obesity;
Visceral fat area;
Glucolipid metabolism;
Insulin resistance
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of visceral fat area (VFA) with glucolipid metabolism indexes and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) complicated with obesity. Methods A total of 315 T2DM patients with obesity who were admitted to the hospital from April 2022 to August 2025 were retrospectively selected. The VFA of all patients was measured by bioelectrical impedance analysis method. According to VFA, the patients were classified into VFA≥100 cm2 group (n=204) and VFA<100 cm2 group (n=111). The glucolipid metabolism indexes [fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C)] and IR index [homeostasis model assessment of insulin resistance based on C-peptide (HOMA-IR(CP))] were detected and compared between both groups of patients. Spearman correlation method was utilized to analyze the correlation between VFA and glucolipid metabolism indexes and HOMA-IR(CP). The independent related factors of VFA were explored by logistic regression analysis. Results According to VFA results of 315 patients after admission, 204 cases (64.76%) had VFA≥100 cm2 and 111 cases (35.24%) had VFA<100 cm2. Compared with the VFA<100 cm2 group, the FPG, HbA1c, TG, TC, LDL-C and HOMA-IR(CP) in the VFA≥100 cm2 group were higher (P<0.05) while the HDL-C was lower (P<0.05). Spearman correlation revealed that VFA≥100 cm2 was positively correlated with FPG, HbA1c, TG, TC, LDL-C and HOMA-IR(CP) (P<0.001), and was negatively correlated with HDL-C (P<0.001). After logistic regression analysis, it was found that FPG, TG, HDL-C, HOMA-IR(CP) and body mass index (BMI) were independent related factors of VFA≥100 cm2 (P<0.05). Conclusion VFA is closely related to glucolipid metabolism and IR in T2DM patients with obesity. FPG, TG, HDL-C, HOMA-IR(CP) and BMI are independent related factors affecting VFA≥100 cm2. However, given the cross-sectional design of this study, the causal timing of this association cannot be determined and needs to be further verified by prospective cohort studies.
