Relationship between retinol binding protein, lipoprotein (a), and obesity and the risk of cardiovascular disease in prehypertensive population
10.3969/j.issn.1006-2483.2026.02.024
- VernacularTitle:视黄醇结合蛋白、脂蛋白（a）水平及肥胖与高血压前期人群
- Author:
Jingjing LI
1
;
Cheng DUAN
1
;
Yuanyuan YAO
1
Author Information
1. Endocrinology Department, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, Anhui 232000, China
- Publication Type:Journal Article
- Keywords:
Prehypertension;
Cardiovascular disease;
Retinol binding protein;
Lipoprotein (a);
Obesity
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between levels of retinol binding protein (RBP) and lipoprotein (a) [Lp(a)], and obesity and the occurrence risk of cardiovascular disease in population with prehypertension (PH). Methods A total of 301 patients with PH who were admitted to the First Affiliated Hospital of Anhui University of Science and Technology for physical examination from July 2021 to July 2024 were selected as the study subjects. The levels of serum RBP and Lp(a) were determined, and the waist circumference (WC) and body mass index (BMI) were measured to evaluate the obesity of patients. All patients were followed up. According to whether cardiovascular disease occurred during the follow-up period, they were classified into a study group (with cardiovascular disease) and a control group (without cardiovascular disease). The effects of serum RBP and Lp(a) levels, WC and BMI on the risk of cardiovascular disease were analyzed. Results The follow-up results showed that 53 out of 301 cases developed cardiovascular disease. The levels of RBP, Lp(a), WC, and BMI in the study group were higher than those in the control group (P<0.05). Receiver operating characteristic curve revealed that the areas under the curves of RBP, Lp(a), WC, and BMI for predicting the cardiovascular disease were 0.823, 0.741, 0.768, and 0.841, respectively. Serum RBP, Lp(a), WC, and BMI were influencing factors of the occurrence of cardiovascular disease (P<0.05). Conclusion RBP, Lp(a), WC, and BMI are the influencing factors for the occurrence of cardiovascular disease in patients with prehypertension. These four indicators have certain predictive value on the occurrence of cardiovascular disease.
