Relationship between protein intake level and inflammation in patients with diabetic kidney disease and its influence on prognosis
10.3969/j.issn.1006-2483.2026.02.023
- VernacularTitle:糖尿病肾病患者蛋白质摄入水平与炎症的关系及对预后的影响
- Author:
Zhe WANG
1
;
Lin ZHOU
1
;
Yi LI
1
Author Information
1. Department of Nephrology, 3201 Hospital, Hanzhong, Shaanxi 723000, China
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease;
Protein intake;
Inflammation;
Prognosis
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship of protein intake level with high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in patients with diabetic kidney disease (DKD) and its influence on prognosis. Methods A total of 325 patients with DKD admitted from June 2021 to June 2024 were included and classified into a low protein group and a high protein group. The levels of hs-CRP, IL-6, and TNF-α were compared between the two groups of patients before follow-up and after 1 year of follow-up. The correlation was analyzed by linear mixed model. The incidence of endpoint events during follow-up and disease progression-free survival time were compared between the two groups. Results The inflammatory indicators exhibited no statistical differences between the two groups before follow-up (P>0.05). After 1 year of follow-up, the levels of hs-CRP, IL-6, and TNF-α in the two groups were higher than those before follow-up, and the levels in the high protein group were higher than those in the low protein group (P<0.05). Linear mixed model analysis suggested that the protein intake level, time, and the interaction term of protein intake level × time were correlated with the changes of hs-CRP, IL-6 and TNF-α levels (P<0.05). The incidence rate of endpoint events in the high-protein group during follow-up was 24.84% (40/161), which was significantly higher than 12.80% (21/164) in the low-protein group (χ2=7.724, P=0.005). The disease progression-free survival time was longer in the low-protein group than that in the high-protein group (Log Rank χ2=9.007, P=0.003). Conclusion The level of protein intake in patients with diabetic kidney disease is closely related to inflammatory response and prognosis.
