Muscle mass reduction and exercise training intervention in non-obese patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2026.02.021
- VernacularTitle:抗阻联合有氧运动对非肥胖2型糖尿病患者肌肉量减少的干预效果
- Author:
Ruihua ZHANG
1
;
Yihan WEI
1
;
Jing XU
1
;
Lina JIANG
1
Author Information
1. Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi , Xinjiang 830013, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Non-obese;
Muscle mass reduction;
Exercise training intervention;
Muscle mass
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):99-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate muscle mass reduction and the effect of exercise training intervention in non-obese patients with type 2 diabetes (T2DM). Methods A total of 324 non-obese patients with T2DM admitted to the First Affiliated Hospital of Xinjiang Medical University were enrolled from February 2023 to February 2025. Dual-energy X-ray absorptiometry was adopted to detect and analyze the data of appendicular skeletal muscle index (ASMI). Non-obese T2DM patients were classified into an observation group (n=162, receive sports training intervention) and a control group (n=162, receiving routine exercise intervention) by adopting random number grouping criteria. Both groups were intervened for 3 months. The muscle mass indicators [ASMI, body mass index (BMI), and body fat rate], exercise ability [6-minute walking distance (6MWD), grip strength, and one-leg standing time], metabolic indicators [fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and homeostasis model assessment insulin resistance index (HOMA-IR)], and quality of life [Diabetes Quality of Life Scale (DQOL)] were compared between the two groups to evaluate the effectiveness of sports training intervention. Results A total of 324 non-obese T2DM patients were enrolled, including 123 cases with reduced muscle mass (37.96%). There were no significant differences in the baseline data and the proportion of patients with muscle mass reduction between the two groups before intervention (P>0.05). After intervention, the ASMI, 6MWD, grip strength, and one-leg standing time in the observation group were higher or longer than those of the control group (P<0.05), while the body fat rate, FPG, HbA1c, HOMA-IR and DQOL scores were lower than those of the control group (P<0.05). Conclusion The incidence of muscle mass reduction is relatively high among non-obese T2DM patients, and exercise training intervention has significant effects on improving muscle mass, metabolic status, exercise capacity and quality of life in non-obese T2DM patients.
