Impact of rapid antiviral therapy on HIV/AIDS mortality outcomes in Wuhan
10.3969/j.issn.1006-2483.2026.02.020
- VernacularTitle:快速抗病毒治疗对武汉市HIV/AIDS死亡结局的影响分析
- Author:
Jie DING
1
;
Xuejiao HU
1
;
Han YAN
1
;
Rong HU
1
;
Pulin LIU
1
Author Information
1. Department for HIV/AIDS Prevention and Control, Wuhan Center for Disease Control and Prevention, Wuhan 430024, China
- Publication Type:Journal Article
- Keywords:
HIV/AIDS;
Rapid antiretroviral therapy;
Death
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):94-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the situation of rapid antiretroviral therapy (ART) and death of HIV/AIDS in Wuhan from 1994 to 2023, and to provide a scientific basis for further rapid initiation of ART and reduction of mortality rate. Methods According to the case follow-up and treatment database of China AIDS Prevention and Control Information System, data were obtained from all the cases reported from January 1, 1994 to December 31, 2023 with the current address in Wuhan City and the review status of the final review card. The data were analyzed using Kaplan-Meier and Cox proportional hazards models. Results The total mortality rate of HIV/AIDS in Wuhan from 1994 to 2023 was 12.76%. The proportion of receiving antiretroviral therapy within 30 days increased year by year, and the mortality rate decreased year by year. After adjusting for sex, age, occupation, ethnicity, education level, mobile population, history of STD, route of infection, source of sample, and first CD4 value, receiving antiretroviral therapy within 30 days (HR=0.08, 95%CI: 0.07-0.10) was a protective factor for HIV/AIDS mortality. Conclusion Rapid antiretroviral therapy can significantly reduce the risk of HIV/AIDS death. A sustainable model of rapid initiation of antiretroviral therapy should be further established to increase the proportion of rapid antiretroviral therapy for HIV/AIDS in Wuhan.
