Comparative analysis of the clinical characteristics of pneumococcal meningitis in different populations in Baoji, Shaanxi Province
10.3969/j.issn.1006-2483.2026.02.013
- VernacularTitle:陕西省宝鸡地区不同人群肺炎链球菌脑膜炎临床特征比较分析
- Author:
Ruize WANG
1
;
Weixuan LI
1
;
Yuanyuan DONG
1
;
Xiaoyu ZHANG
2
;
Tiantian ZHOU
1
;
Dan ZHANG
1
;
Weijun HU
1
Author Information
1. Shaanxi Provincial Center for Disease Control and Prevention, Xi'an , Shaanxi 710054, China
2. Immunization Program Institute of Baoji City Center for Disease Control and Prevention, Baoji , Shaanxi 721000, China
- Publication Type:Journal Article
- Keywords:
Streptococcus pneumoniae;
Meningitis;
Biochemical indicator
- From:
Journal of Public Health and Preventive Medicine
2026;37(2):59-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical characteristics of pneumococcal meningitis in different age groups, and to provide a basis for early diagnosis of pneumococcal meningitis. Methods Cerebrospinal fluid and/or serum samples were collected from 1742 suspected cases of meningitis in Baoji, Shaanxi Province from August 2013 to July 2019. Streptococcus pneumoniae was detected by isolation culture and real-time fluorescence quantitative polymerase chain reaction. Retrospective analysis of clinical manifestations, biochemical indicators and other information of laboratory confirmed cases was conducted by χ2 test or Fisher's exact test. Results A total of 1742 samples of encephalitis or meningitis cases were detected, and 41 cases were confirmed as laboratory-confirmed Streptococcus pneumoniae infection. Among them, there were 12 cases (29.27%) in the infant group, 14 cases (34.15%) in the child group, and 15 cases (36.59%) in the adult group. The proportion of the adults with headache was significantly higher than that of the infants (χ2=11.408，P＜0.017). The proportion of the adults with consciousness disorder, elevated white blood cells and elevated neutrophils were significantly higher than those in the infant and the child groups（Fisher's exact test, P＜0.017；χ2 =6.428，P＜0.017；χ2 =10.898，P＜0.017；χ2 =6.421，P＜0.017；χ2 =9.758，P＜0.017；χ2 =7.744，P＜0.017). The proportion of the infants with cerebrospinal fluid turbidity was significantly higher than that of the children (Fisher's exact test，P＜0.017). The proportion of the infants with decreased white blood cells and reduced glucose in cerebrospinal fluid was significantly higher than that of the children group and the adult group（Fisher's exact test, P＜0.001；Fisher's exact test, P＜0.001；Fisher's exact test, P＜0.017; Fisher's exact test, P＜0.017). Conclusion Most adult patients with pneumococcal meningitis have headache and consciousness disorders, with significantly increased proportion of white blood cells and neutrophils. Infant patients tend to have cloudy appearance of cerebrospinal fluid, leukopenia in blood, and decreased glucose in cerebrospinal fluid.
