Research progress on the mechanism of traditional Chinese medicine intervening in osteoarthritis by modulating the inflammatory microenvironment
- VernacularTitle:中药调控炎症微环境干预骨关节炎的机制研究进展
- Author:
Zuo WANG
1
;
Yuxin LIU
2
;
Yuxin QIAO
1
;
Zhengyu YANG
1
;
Ru WANG
1
;
Wenbin LIAO
3
;
Yan GAO
1
;
Jiayi FENG
1
;
Guohua LI
1
Author Information
1. College of Clinical Chinese Medicine，Inner Mongolia Medical University，Hohhot 010107，China
2. Dept. of Rheumatology，Ordos Hospital of Traditional Chinese Medicine，Inner Mongolia Ordos 017010，China
3. Dept. of Rheumatology，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010020，China
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
inflammatory microenvironment;
TCM monomer;
active ingredients;
herb pairs;
TCM formulas
- From:
China Pharmacy
2026;37(6):823-828
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory microenvironment is closely associated with the initiation and progression of osteoarthritis （OA）， specifically manifesting as macrophage activation， dysregulation of inflammatory cytokines， and redox imbalance. Following an overview of the pathological characteristics of the OA inflammatory microenvironment， this paper reviews the research progress on the mechanism of traditional Chinese medicine （TCM） intervening in OA by modulating the inflammatory microenvironment. It has been found that TCM monomers/active ingredients （such as total alkaloids from Strychnos nux-vomica ， quercetin， triptolide， etc.）， herb pairs （e.g. Angelica pubescens - Gentiana macrophylla ， Carthami Flos-Lycopodii Herba）， and TCM formulas （such as Zhuanggu jianxi formula， Duhuo jisheng decoction and Rongjin niantong formula， etc.） can inhibit macrophage activation， reduce the release of proinflammatory cytokines and the generation of reactive oxygen species by inhibiting multiple signaling pathways， including nuclear factor-κB， Wnt/ β -catenin， and mitogen-activated protein kinase， thereby alleviating the articular inflammatory microenvironment， restoring local joint homeostasis， and slowing the progression of OA.
