Study on the absorption-enhancing effect of self-assembled nanoparticles from Shaoyao gancao decoction
- VernacularTitle:芍药甘草汤自组装纳米粒的促吸收作用研究
- Author:
Xinling WEI
1
;
Shuangchen ZHANG
2
;
Nianzhan ZHANG
2
;
Yican HE
3
;
Chaoying DU
4
;
Baode SHEN
2
;
Chengying SHEN
4
Author Information
1. School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China;Dept. of Pharmacy，Jiangxi Provincial People’s Hospital （the First Affiliated Hospital of Nanchang Medical College），Nanchang 330006，China
2. Key Laboratory of Modern Preparation of Traditional Chinese Medicine，Ministry of Education，Jiangxi University of Chinese Medicine，Nanchang 330004，China
3. Dept. of Pharmacy，Jiangxi Provincial People’s Hospital （the First Affiliated Hospital of Nanchang Medical College），Nanchang 330006，China;School of Pharmacy，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
4. Dept. of Pharmacy，Jiangxi Provincial People’s Hospital （the First Affiliated Hospital of Nanchang Medical College），Nanchang 330006，China
- Publication Type:Journal Article
- Keywords:
Shaoyao gancao decoction;
self-assembled nanoparticles;
in-situ single-pass intestinal perfusion;
Ka;
Peff
- From:
China Pharmacy
2026;37(6):713-719
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect and mechanism of self-assembled nanoparticles from Shaoyao gancao decoction （SGD-SAN） on the intestinal absorption behavior of its main active components. METHODS SGD-SAN was prepared and characterized. Using an in-situ single-pass intestinal perfusion model in rats， the absorption characteristics of five active components （albiflorin， paeoniflorin， liquiritin apioside， liquiritin， glycyrrhizic acid） from SGD-SAN in the jejunum and ileum were studied， with the absorption rate constant （ K a ） and apparent permeability coefficient （ P eff ） as indicators， and compared with free drugs. In the intestinal segment with optimal absorption， the effects of drug concentration and efflux transporter inhibitors （P-glycoprotein inhibitor verapamil， multidrug resistance-associated protein 2 inhibitor indomethacin， breast cancer resistance protein inhibitor reserpine） on the intestinal absorption characteristics of these components were examined. RESULTS The obtained SGD-SAN exhibited a spherical shape with uniform sizes， an average particle diameter of （155.57±2.65） nm， a polydispersity index of 0.34±0.03， and a Zeta potential of （－9.30±1.12） mV. The average total content of five active components， including albiflorin， was 12.26%， and remained unaffected by enzymatic degradation and intestinal physical absorption. Compared with the free drug group， the five active components in the SGD-SAN group exhibited higher absorption rates in the ileal segment， with significantly elevated K a and P eff values （except for the P eff value of glycyrrhizic acid in the ileal segment） （ P ＜0.05 or P ＜0.01）. Their absorption demonstrated a concentration-dependent trend. In the free drug groups， the absorption of each component was regulated by corresponding inhibitors （ P ＜0.05 or P ＜0.01）； whereas in the SGD-SAN groups， except for albiflorin and paeoniflorin， the absorption of the remaining components was not affected by the inhibitors （ P ＞0.05）. CONCLUSIONS SGD-SAN significantly enhances the intestinal absorption efficiency of active components. The above absorption-enhancing effect may be related to the avoidance of efflux transporter influence and the presence of a mixed absorption mode.
