Determination of carbonate compounds in workplace air by gas chromatography-mass spectrometry
10.20001/j.issn.2095-2619.20251213
- VernacularTitle:气相色谱-质谱联用法检测工作场所空气中碳酸酯类化合物
- Author:
Pengwei LIU
1
;
Yulai TIAN
;
Xiaowei FANG
;
Jing ZHANG
;
Xiang CHEN
;
Zhonglin ZHAO
Author Information
1. Laboratory of Center, Shanghai Institute of Occupational Disease for Chemical Industry, Shanghai 200041, China
- Publication Type:Journal Article
- Keywords:
Workplace;
Air;
Carbonate compounds;
Ethyl methyl carbonate;
Diethyl carbonate;
Vinylene carbonate;
Ethylene carbonate;
Gas chromatography-mass spectrometry
- From:
China Occupational Medicine
2025;52(6):672-676
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a gas chromatography-mass spectrometry (GC-MS) method for the simultaneous determination of four carbonate compounds (CCs), including ethyl methyl carbonate (EMC), diethyl carbonate (DEC), vinylene carbonate (VC), and ethylene carbonate (EC) in workplace air. Methods Vapor-phase EMC, DEC, VC, and EC in workplace air were collected using activated carbon tubes. After desorption with dichloromethane, the samples were analyzed by GC-MS. Qualitative identification was performed based on retention times and characteristic ions, while quantitative analysis was conducted using peak areas of selected characteristic ions. Results The quantitative determination ranges for the four CCs were from 0.57×10⁻³ to 200.00 mg/L, with correlation coefficients ≥0.999 45. The detection limit ranged from 0.17 to 1.60 μg/L, and the lower limit of quantification ranged from 0.57 to 5.33 μg/L. The minimum detection concentration and minimum quantitation concentration were 0.11-1.07 and 0.38-3.55 μg/m³, respectively. Mean spiked recoveries ranged from 85.70% to 111.65%. The intra- and inter-batch relative standard deviations were 0.11%-2.04% and 1.27%-5.18%, respectively. Mean desorption efficiencies of the method ranged from 74.70% to 118.20%. EMC, DEC, and EC samples were stable for up to five days at 4 °C, while VC samples were stable for up to three days at 4 °C. Conclusion The GC-MS method is suitable for the simultaneous determination of the four CCs including EMC, DEC, VC, and EC in workplace air.
