Interventional effect and mechanism of Bifidobacterium in chronic liver disease
- VernacularTitle:双歧杆菌对慢性肝病的干预作用及其机制
- Author:
Liyi PAN
1
;
Yueqiao CHEN
2
;
Yu CHEN
1
;
Yuyun HUANG
1
;
Hao PEI
1
;
Fenglan WU
1
;
Lyuping YE
2
;
Na WANG
2
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; Bifidobacterium; Signal Transduction
- From: Journal of Clinical Hepatology 2026;42(2):464-471
- CountryChina
- Language:Chinese
- Abstract: Compared with traditional therapies for chronic liver disease （CLD）， Bifidobacterium has the characteristics of multi-target intervention， high biosafety， and good host compatibility and provides new strategies for intervention of CLD progression in terms of microecological regulation. Various studies have shown that Bifidobacterium regulates liver homeostasis and exerts a therapeutic effect on CLD by regulating intestinal flora， maintaining antioxidation， promoting energy consumption， alleviating inflammation， improving glycolipid metabolism， and exerting an antitumor effect. This article systematically reviews the studies on Bifidobacterium in the treatment of CLD in China and globally， explores their different mechanisms， and elaborates on the interaction between related signaling pathways （such as the nuclear factor erythroid 2-related factor 2 signaling pathway and the adenosine monophosphate-activated protein kinase signaling pathway） and the liver， in order to provide a basis for probiotic intervention in liver pathology， as well as new ideas for the comprehensive treatment of CLD.
