The mechanism and clinical characteristics in comorbidity of autoimmune liver diseases and autoimmune thyroid diseases
- VernacularTitle:自身免疫性肝病与自身免疫性甲状腺疾病共病的机制及临床特点
- Author:
Yinghui RAN
1
;
Wei LU
1
;
Fumei YANG
1
;
Xiaohong LI
1
;
Rong ZHU
1
Author Information
- Publication Type:Review
- Keywords: Hepatitis， Autoimmune; Thyroid Disease; Comorbidity
- From: Journal of Clinical Hepatology 2026;42(2):432-437
- CountryChina
- Language:Chinese
- Abstract: Autoimmune liver diseases （AILD） are a group of chronic liver diseases caused by abnormal activation of the immune system， mainly including autoimmune hepatitis， primary biliary cholangitis， primary sclerosing cholangitis， IgG4-related sclerosing cholangitis， and overlap syndrome. Clinical studies have shown that patients with AILD are often comorbid with thyroid diseases， especially autoimmune thyroid diseases （AITD）， such as Graves’ disease and Hashimoto’s thyroiditis. This article systematically reviews the epidemiological association， potential shared pathogenesis， and overlapping features between AILD and thyroid diseases. A deeper understanding of the immunological links between AILD and AITD may provide a theoretical basis for precision medicine and future research.
