Activation patterns and mechanism in the prefrontal cortex of post-stroke anxiety patients: a study using functional near-infrared spectroscopy
10.3969/j.issn.1006-9771.2026.03.009
- VernacularTitle:基于功能性近红外光谱成像的卒中后焦虑患者前额叶皮质激活特征及机制研究
- Author:
Ling YANG
1
;
Qinglei WANG
2
;
Jie WANG
1
;
Wenjie XU
1
;
Tong WANG
2
;
Chuan GUO
2
;
Xue QIAN
1
Author Information
1. Changzhou De'an Hospital, Changzhou, Jiangsu 213004, China
2. The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
- Publication Type:Journal Article
- Keywords:
stroke;
post-stroke anxiety;
functional near-infrared spectroscopy;
functional connectivity;
cortical activation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2026;32(3):329-336
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the activation patterns and functional connectivity in the prefrontal cortex of patients with post-stroke anxiety (PSA) using functional near-infrared spectroscopy, in order to explore the underlying neural mechanism. MethodsFrom December, 2024 to September, 2025, 120 stroke patients were selected in Changzhou De'an Hospital. They were divided into PSA group (n = 60) and non-PSA group (n = 60) according to the score of Hamilton Anxiety Scale (HAMA). All patients wore an 18-channel fNIRS acquisition cap for detection. The differences in resting-state functional connectivity between the frontopolar cortex (FPC) and dorsolateral prefrontal cortex (DLPFC) were examined in both groups, as well as task-related activation in these brain regions. ResultsResting-state functional connectivity analysis revealed no statistically significant difference in network connectivity between two groups in the FPC and DLPFC regions (|t| < 1.301, P > 0.05). Task-related activation results revealed significantly reduced activation in the contralateral FPC of PSA group compared to the non-PSA group (Z = -2.063, P < 0.05). Activation levels in this region showed a negative correlation with the scores of HAMA (ρ = -0.201, P = 0.028). ConclusionActivation decreased in the contralateral frontal pole during the task state for patients with PSA, and the activation levels negatively correlates with anxiety severities.
