Research Progress on Predictive Value of Inflammatory and Nutritional Indicators for Prognosis of Nasopharyngeal Carcinoma in the Era of Immunotherapy
10.3971/j.issn.1000-8578.2026.25.0795
- VernacularTitle:免疫治疗时代下炎症营养指标对鼻咽癌的预后预测价值研究进展
- Author:
Minglei CAI
1
;
Ying LU
1
;
Yajuan ZHOU
1
Author Information
1. Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China.
- Publication Type:REVIEWS
- Keywords:
Nasopharyngeal carcinoma;
Inflammatory and nutritional indicators;
Prognostic assessment;
Immunotherapy
- From:
Cancer Research on Prevention and Treatment
2026;53(3):226-232
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma (NPC) is endemic to southern China. Currently, its treatment and prognosis reply primarily on the TNM staging system and EBV-DNA testing; however, these parameters have limitations in fully capturing the tumor’s biological heterogeneity and the host's immunonutritional status. In recent years, systemic inflammatory and nutritional indices, such as the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), prognostic nutritional index (PNI), and skeletal muscle index (SMI), have proven effective for assessing systemic inflammation and nutritional status. Accumulating evidence has demonstrated that these indicators are closely associated with treatment response, progression-free survival (PFS), and overall survival (OS) in NPC patients, and also show promise in predicting the efficacy of immune checkpoint inhibitors. This review aims to systematically elaborate on the prognostic value of these inflammatory and nutritional indicators in the context of NPC immunotherapy, to inform the development of individualized precision treatment strategies.
