Research Progress on Treatment of Liver Cancer with Mechanistic Insights into Herbal Medicine: Focus on NF-κB Signaling Pathway
10.3971/j.issn.1000-8578.2026.25.0658
- VernacularTitle:基于NF-κB信号通路探讨中药治疗肝癌的研究进展
- Author:
Tianke HUANG
1
;
Aize XIE
2
Author Information
1. Traditional Chinese Medicine Department, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
2. Traditional Chinese Medicine Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.
- Publication Type:REVIEWS
- Keywords:
NF-κB signaling pathway;
Traditional Chinese medicine;
Liver cancer;
Apoptosis;
Multi-target therapy
- From:
Cancer Research on Prevention and Treatment
2026;53(3):211-218
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer ranks among malignancies with high global incidence and mortality rates, presenting significant therapeutic challenges. The NF-κB signaling pathway plays a pivotal role in pathogenesis, progression, and treatment of liver cancer, where its aberrant activation is intricately linked to tumor cell proliferation and the dysregulation of apoptosis. In recent years, targeting the inhibition of this pathway has become an important research direction in the treatment of liver cancer. Traditional Chinese medicine (TCM), characterized by multicomponent nature and multitarget effects, exhibits unique advantages in the management of liver cancer. In this article, the regulatory mechanisms of the NF-κB signaling pathway in liver cancer are systematically reviewed, and the research progress on how TCM exerts antitumor effects by inhibiting this pathway and inducing apoptosis in liver cancer cells is summarized. This work provides a theoretical basis and new insights for the study of single compounds and compound formulations of TCM against liver cancer.
