Traditional Chinese Medicine Intervention in Parkinson's Disease Based on Keap1/Nrf2/ARE Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20241916
- VernacularTitle:基于Keap1/Nrf2/ARE信号通路探讨中医药干预帕金森病的研究进展
- Author:
Liuping YUE
1
;
Yongkang SUN
1
;
Fangbiao XU
1
;
Yanbo SONG
1
;
Yijun WU
1
;
Huan YU
1
;
Xinzhi WANG
1
Author Information
1. Encephalopathy Center， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450099，China
- Publication Type:Journal Article
- Keywords:
Kelch-like ECH-associated protein 1 （Keap1）/nuclear factor E2 related factor 2 （Nrf2）/antioxidant response element （ARE）;
signaling pathway;
traditional Chinese medicine;
Parkinson's disease;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(9):307-317
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease （PD） is a chronic progressive neurodegenerative disorder primarily characterized by motor dysfunction. The main pathological features include the loss of dopaminergic neurons in the substantia nigra， abnormal aggregation of alpha-Synuclein （α-Syn）， and the formation of Lewy bodies. However， the exact mechanisms remain unclear. In recent years， the PD incidence has gradually increased， while current treatment methods are limited to symptom alleviation， incapable of halting disease progression， and prone to adverse effects， thus making it urgent to search for medicines effective for PD. Modern research indicates that the Kelch-like ECH-associated protein 1 （Keap1）/nuclear factor E2 related factor 2 （Nrf2）/antioxidant response element （ARE） signaling pathway is closely related to oxidative stress， neuroinflammation， apoptosis， ferroptosis， and mitochondrial dysfunction， playing a crucial role in the pathophysiological development of PD. A large number of studies have further confirmed that traditional Chinese medicine （TCM） can regulate diseases through a holistic view of Syndrome differentiation and microscopic molecular pathways. With unique advantages， such as multiple targets， multiple pathways， and fewer adverse reactions， TCM provides a new strategy for PD treatment. This article elucidates the mechanism of the Keap1/Nrf2/ARE signaling pathway in the occurrence and development of PD， while summarizing the latest research on PD intervention by TCM monomers， active ingredients， and compounds， as well as acupuncture via the precise targeted regulation of the Keap1/Nrf2/ARE pathway， aiming to provide a reference for clinical medicine development to prevent and treat PD.
