The role of P2X7R in cardiac remodeling
10.19405/j.cnki.issn1000-1492.2025.07.028
- VernacularTitle:P2X7R 在心肌重构中的作用
- Author:
Shasha Yang
1
;
Lihua Mo
1
;
Huibo Wang
1
Author Information
1. Institute of Cardiovascular Diseases，China Three Gorges University，Yichang 443003 ; Dept of Cardiology，First Clinical Medical College，China Three Gorges University，Yichang 443003
- Publication Type:Journal Article
- Keywords:
P2X7R;
cardiovascular disease;
cardiac remodeling;
myocardial fibrosis;
myocardial hypertrophy;
heart failure
- From:
Acta Universitatis Medicinalis Anhui
2025;60(7):1359-1364
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Cardiovascular disease is one of the leading causes of death worldwide, and myocardial remodeling is at the core of the development and progression of most cardiovascular diseases. Purinergic ligand-gated ion channel 7 receptor(P2X7R) is a member of the purinergic receptor family, which is expressed in immune cells, cardiac smooth muscle cells, and endothelial cells, and plays an important role in pathological processes related to immune system regulation, neuroprotection, and inflammatory responses. Activation of P2X7R plays an important role in myocardial remodeling, including myocardial fibrosis, myocardial hypertrophy, and heart failure. Therefore, this article reviews the structural and functional properties of P2X7R and its mechanism of action in myocardial remodeling.
- Full text:2026041714143950685P2X7R在心肌重构中的作用_杨莎莎.pdf
