Human serine metabolism and related diseases
10.19405/j.cnki.issn1000-1492.2025.07.027
- VernacularTitle:人体内丝氨酸代谢及其相关性疾病的研究进展
- Author:
Guilin Zhao
1
;
Xinglin Mo
1
;
Lan Zhen
1
;
Ruzhou Zhao
2
;
Feixiang Wu
3
Author Information
1. Hepatobiliary Surgery Dept，Guangxi Medical University Cancer Hospital，Nanning 530021 ; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor ( Guangxi Medical University) ，Nanning 530021; Laboratory of Advanced Biotechnology， Academy of Military Medical Sciences，Academy of Military Sciences，Beijing 100850
2. Laboratory of Advanced Biotechnology， Academy of Military Medical Sciences，Academy of Military Sciences，Beijing 100850
3. Hepatobiliary Surgery Dept，Guangxi Medical University Cancer Hospital，Nanning 530021 ; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor ( Guangxi Medical University) ，Nanning 530021
- Publication Type:Review
- Keywords:
serine metabolism;
glycine;
one-carbon metabolism;
metabolic syndrome;
cancer;
nervous system diseases
- From:
Acta Universitatis Medicinalis Anhui
2025;60(7):1351-1358
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Serine is a non-essential amino acid that plays a key role in the synthesis of biomolecules such as proteins, nucleotides and lipids, and changes in the uptake, absorption, synthesis and catabolic levels of serine in vivo all affect multiple physiological processes in tissue cells. Serine plays a key role in intracellular energy metabolism and signaling linkages, and has a profound impact on the developmental processes of a variety of metabolic diseases, cancer, neurodegenerative diseases and aging. In-depth study of serine metabolic pathways can provide new targets and strategies for early diagnosis, treatment and prevention of related diseases. Based on the physiological function of serine, this article expounds the synthetic and metabolic transformation of serine in cells, and reviews the research progress of intracellular serine metabolism on cell physiology and related diseases at home and abroad, which provides a theoretical reference for serine metabolism as an emerging target for disease treatment.
- Full text:2026041714105651662人体内丝氨酸代谢及其相关性疾病的研究进展_赵桂霖.pdf
