Interpretation of the role of circadian rhythm health in cardiometabolic health and disease risk: The scientific statement from the American Heart Association
- VernacularTitle:《昼夜节律健康在心脏代谢健康和疾病风险中的作用：美国心脏协会的科学声明》解读
- Author:
Zixiong NIE
1
;
Honghua YUE
1
;
Weitao LIANG
1
;
Zhong WU
1
Author Information
1. Department of Cardiothoracic and Vascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
- Publication Type:Journal Article
- Keywords:
Circadian rhythm;
cardiovascular diseases;
type 2 diabetes mellitus;
exercise;
scientific statement;
interpretation
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(04):543-549
- CountryChina
- Language:Chinese
-
Abstract:
The circadian system maintains physiological homeostasis by precisely orchestrating 24-hour cycles of metabolic and cardiovascular functions. Circadian disruption has been substantiated as a contributor to cardiometabolic dysfunction, significantly elevating the risk of obesity, type 2 diabetes, hypertension, and cardiovascular diseases, thereby emerging as a crucial target for global chronic disease prevention. In 2025, the American Heart Association (AHA) issued a dedicated scientific statement that systematically reviewed the regulatory mechanisms of circadian rhythms and their intrinsic links to cardiometabolic health. It highlighted the pivotal role of modifiable behavioral factors, including light exposure, sleep-wake patterns, meal timing, and timing of physical activity, and proposed multi-faceted intervention strategies centered on chronotherapy. Considering the distinct circadian characteristics and chronic disease epidemiology in the Chinese population compared to Western counterparts, this article, grounded in the statement's core framework and incorporating evidence from localized Chinese research, provides a systematic interpretation of the biological basis of circadian rhythms, the pathophysiological mechanisms underlying disruption-related diseases, and potential intervention pathways. It particularly discusses the applicability of the statement's conclusions to clinical practice and public health strategies in China, aiming to offer an evidence-based reference for developing a cardiometabolic health support system tailored to the national context.
