Correlation of pan-immune inflammation value with primary IgA nephropathy
10.19405/j.cnki.issn1000-1492.2025.07.024
- VernacularTitle:泛免疫炎症值与原发性 IgA 肾病的相关性分析
- Author:
Jingwen Zhu
1
;
Yonggui Wu
1
Author Information
1. Dept of Nephropathy，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
primary glomerulonephritis;
IgA nephropathy;
pan-immune inflammation value;
clinical and pathological;
renal biopsy;
podocyte injury
- From:
Acta Universitatis Medicinalis Anhui
2025;60(7):1333-1339
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the correlation between the pan-immune inflammation value (PIV) and clini- cal and pathological features of primary IgA nephropathy (IgAN) ，and to evaluate the clinical significance of PIV in primary IgAN．
Methods:200 patients with primary IgAN diagnosed by renal biopsy were selected as the re- search subjects．General information，laboratory indicators，pathologic features of renal biopsy，and calculations of platelet to lymphocyte count ratio(PLR) ，neutrophil to lymphocyte count ratio(NLR) ，PIV，and other relevant in- dices about patients were collected．According to the median PIV，subjects were divided into low PIV group (PIV ≤194. 81) and high PIV group ( PIV ＞194. 81) ，and the clinical and pathological data of the two groups were compared and analyzed．Using Spearman rank correlation analysis and logistic regression analysis，the relationship between PIV and primary IgAN in terms of clinical and pathological aspects was explored．
Results:There were sta- tistical significance in age，gender，height，hyperuricemia，hemoglobin，absolute neutrophil count (ANC) ，absolute monocytes count，platelet，PLR , NLR , serum uric acid，immunoglobulin G(IgG) ，immunoglobulin A(IgA) / com- plement 3 ( C3) ，and fusion degree of the podocyte foot between the two sets (P＜0. 05) ．The result of correlation analysis indicated that PIV was positively correlated with ANC，platelet，absolute monocytes count，PLR , NLR , serum creatinine，C3，serum uric acid，and fusion degree of the podocyte foot，but negatively correlated with IgG， IgA/ C3，IgA/ C4．The degree of podocyte foot process fusion was positively correlated with PIV，ANC，total choles- terol，and 24-hour urinary protein to creatinine ratio，and negatively correlated with albumin(ALB) ，IgG，IgA，and IgA/ C3．Logistic regression analysis further indicated that ALB was an independent protective factor for the occur- rence of podocyte foot process fusion in primary IgAN，and PIV was an independent risk factor for the occurrence of podocyte foot process fusion in primary IgAN．
Conclusion:PIV is closely related to the clinical symptoms and pathological lesions of primary IgAN．ALB is an independent protective factor for the occurrence of podocyte foot process fusion in primary IgAN，and PIV is an independent risk factor for the occurrence of podocyte foot process fu- sion in primary IgAN，which can be used as an auxiliary indicator of clinical and pathological results，providing valuable information for risk assessment and treatment plan formulation of primary IgAN．
- Full text:2026041423203119279泛免疫炎症值与原发性IgA肾病的相关性分析_朱静雯.pdf
