The expression level and clinical significance of ET-1 in idiopathic inflammatory demyelinating diseases of central nervous system
10.19405/j.cnki.issn1000-1492.2025.07.022
- VernacularTitle:ET －1 在中枢神经系统特发性炎性脱髓鞘 疾病中的表达及其临床意义
- Author:
Chenrui Song
1
;
Yanqun Liu
2
;
Xiaoying Bi
2
Author Information
1. Dept of Neurology，The First Affiliated Hospital of Naval Medical University，Shanghai 200433;Dept of Neurology，The Third Hospital of Naval Medical University，Shanghai 201805
2. Dept of Neurology，The First Affiliated Hospital of Naval Medical University，Shanghai 200433
- Publication Type:Journal Article
- Keywords:
idiopathic inflammatory demyelinating disease of the central nervous system;
endothelin-1;
vascular demyelinating diseases of the central nervous system;
central nervous system inflammation;
disability severity;
emotional-cognitive function
- From:
Acta Universitatis Medicinalis Anhui
2025;60(7):1319-1324
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To examine the relationship between the levels of endothelin-1(ET-1) and the severity of clinical symptoms in idiopathic inflammatory demyelinating diseases(IIDDs) of the central nervous system.
Methods :A total of 45 patients with central nervous system demyelinating diseases were enrolled in the study. Among them, 25 patients were diagnosed with idiopathic IIDDs, 20 had vascular demyelinating diseases of the central nervous system, and 10 healthy controls were also included. Serum ET-1 levels were assessed using ELISA, and a further analysis was conducted to investigate the correlation between these ET-1 levels, laboratory test results, and the degree of disease disability in the IIDDs patient group.
Results:(1) Of the three groups, ET-1 levels were highest in the IIDDs(Ps=0.503, P=0.010), CSF total protein(rs=0.475, P=0.016), CSF albumin(rs=0.480, P=0.020), CSF IgG(rs=0.544, P=0.007), IgA(rs=0.660, P=0.002) and IgM(rs=0.555, P=0.011) levels.(3) There was a positive correlation between serum ET-1 levels and CSF IgM levels(rs=0.455, P=0.044) in IIDDs group. Serum ET-1 level showed no significant correlation with peripheral immune reaction(P>0.05).
Conclusion:Serum ET-1 levels reflect the severity of clinical symptoms in IIDDs and show no significant correlation with peripheral immune markers, however, exhibit a positive correlation with disease severity and cerebrospinal fluid IgM levels. These findings suggest that serum ET-1 levels may indicate the degree of central nervous system inflammation and play an important role in the development and progression of IIDDs.
- Full text:2026041423141091997ET-1在中枢神经系统特发性炎性脱髓鞘疾病中的表达及其临床意义_宋晨蕊.pdf
