Association between LE8 and diabetes and the mediating role of methylmalonic acid
10.19405/j.cnki.issn1000-1492.2025.07.020
- VernacularTitle:LE8 评分与糖尿病的关系及甲基丙二酸 的中介效应分析
- Author:
Bingrui Ling
1
;
Qihui Huang
1
;
Tianfeng Hua
1
;
Min Yang
1
;
Lunxian Tang
2
Author Information
1. The Second Dept of Intensive Care Unit，The Laboratory of Cardiopulmonary Resuscitation and Critical Care Medicine，The Second Affiliated Hospital of Anhui Medical University，Hefei 230601
2. The Second Dept of Intensive Care Unit，The Second Affiliated Hospital of Anhui Medical University，Hefei 230601;Dept of Emergency Internal Medicine，Shanghai East Hospital，School of Medicine， Tongji University，Shanghai 200120
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
life′s essential 8;
methylmalonic acid;
mediation analysis;
weighted multivariable Logistic regression;
national health and nutrition examination survey
- From:
Acta Universitatis Medicinalis Anhui
2025;60(7):1305-1311
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association between Life eight ( LE8) scores and diabetes mellitus ( DM) ， and to examine the mediating effect of Methylmalonic acid (MMA).
Methods:Based on cross-sectional data from the 2011—2014 National Health and Nutrition Examination Survey (NHANES) ，weighted multivariable logistic regression analyses were conducted to assess the association between the LE8 score and DM．A mediation model was further constructed to evaluate the mediating effect of MMA．
Results:The weighted multivariable logistic regression analysis showed a significant negative correlation between LE8 score and the risk of DM．After adjusting for poten- tial confounders，a 1-point increase in LE8 was associated with a 7% reduction in DM risk ( OR = 0. 93，95% CI: 0. 92－0. 93，P = 0. 000 1) ．In contrast，the level of circulating MMA did not show a statistically significant rela- tionship with DM risk ( OR = 0. 99，95% CI: 0. 89 －1. 10，P = 0. 886 8) ．Further subgroup analysis by age re- vealed that in participants under 60 years of age，circulating MMA levels were positively associated with DM risk ( OR = 1. 39，95% CI: 1. 19 －1. 62 ，P ＜0. 000 1 ) ． Mediation analysis indicated that circulating MMA levels played a partial mediating role in the relationship between LE8 and DM，with a mediation ratio of 1. 5% (P < 0. 000 1) ．
Conclusion:High LE8 scores significantly reduce the risk of DM ，and circulating MMA levels may play a role in this，particularly among individuals younger than 60 years (individuals＜60 years of age
- Full text:2026041423034358778LE8评分与糖尿病的关系及甲基丙二酸的中介效应分析_凌炳睿.pdf
