Benvitimod attenuates atopic dermatitis by regulating the NRF2/ROS/NLRP3 signaling pathway
10.19405/j.cnki.issn1000-1492.2025.08.018
- VernacularTitle:本维莫德调控 NRF2/ROS/NLRP3 通路减轻特应性皮炎
- Author:
Yun Lu
1
;
Liping Dong
1
;
Maoxin Huang
1
;
Yu Wang
1
;
Tingyue Deng
1
;
Fengli Xiao
2
Author Information
1. Dept of Dermatology, The First Afiliated Hospital of Anhui Medical University, Hefei 230022 ; Institute of Dermatology, Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education , Hefei 230032
2. Dept of Dermatology, The First Afiliated Hospital of Anhui Medical University, Hefei 230022 ; Institute of Dermatology, Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education , Hefei 230032;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province , Hefei 230032
- Publication Type:Journal Article
- Keywords:
benvitimod;
atopic dermatitis;
pyroptosis;
NLRP3;
NRF2;
ROS
- From:
Acta Universitatis Medicinalis Anhui
2025;60(8):1490-1497,1505
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the mechanism of action of benvitimod (BVM) in the treatment of atopic der- matitis (AD) .
Methods :HaCaT cells were stimulated by TNF-α and IFN-γ , and the cells were grouped into NC group , TNF-α/IFN-γ group , TNF-α/IFN-γ BVM group , and TNF-α/IFN-γ BVM ML385 group. The AD model of DNCB-induced Balb/c mice was divided into CON group , DNCB group , DNCB + BVM group , and DNCB + TAC group. The efficacy of BVM and its roles in antioxidant and pyroptosis regulation were evaluated.
Results:Compared with the control group , BVM inhibited the inflammatory response of HaCaT cells stimulated by TNF-α and IFN-γ , and ameliorated the skin lesions and inflammation in the DNCB-induced AD mouse model ; at the same time , it significantly increased the expression of nuclearfactorerythroid-2-relatedfactor2 (NRF2)-related anti-oxida- tive stress proteins , and significantly reduced the expression of cellular reactive oxygen species (ROS) levels and pyroptosis proteins. At the same time , the levels of NRF2-related antioxidative stress proteins significantly in- creased , and the levels of ROS and pyroptosis proteins significantly decreased.
Conclusion:BVM activates the NRF2/ROS/NLRP3 pathway to inhibit pyroptosis , thereby reducing the inflammatory response in AD.
- Full text:2026041112035977253本维莫德调控NRF2_ROS_NLRP3通路减轻特应性皮炎_陆芸.pdf
