Effect of lipopolysaccharide binding protein on scald wound healing in mice
10.19405/j.cnki.issn1000-1492.2025.08.016
- VernacularTitle:脂多糖结合蛋白对小鼠烫伤创面愈合的影响
- Author:
Min Zhong
1
;
Yexiang Sun
1
;
Haoshu Fang
2
Author Information
1. Dept of Burns , The First Afiliated Hospital of Anhui Medical University , Hefei 230022
2. Dept of Burns , The First Afiliated Hospital of Anhui Medical University , Hefei 230022;Dept of Pathophysiology , School of Basic Medical Sciences , Anhui Medical University , Hefei 230032
- Publication Type:Journal Article
- Keywords:
lipopolysaccharide⁃binding protein;
scald model;
wound repair;
lipid metabolism;
protein therapy
- From:
Acta Universitatis Medicinalis Anhui
2025;60(8):1478-1484
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the effects of lipopolysaccharide⁃binding protein (LBP) on the skin reconstruc⁃tion process and to compare the differences in the healing rate and healing quality of scald wounds in C57BL/6J wild⁃type (WT) mice and LBP knockout ( LBP - / - ) mice were compared.
Methods:Based on WT mice and periodically after scald injury , and images were acquired and weighed. After the scar matured , the material was taken for HE staining , oil red staining and Masson staining , which were used to assess the quality of the newborn skin.
Results:The wound healing time of WT mice and LBP - / - mice was 18 days and 24 days , respectively. The results of pathological staining of skin tissue showed that compared with WT mice , the skin of LBP - / - mice had thinner new fat layer, fewer hair follicles and dysplasia of accessory glands. The mature scar tissue of LBP - / - mice was thicker and the collagen content was higher.
Conclusion:After scalding in LBP - / - mice , due to the lack of LBP , the wound healing rate is slowed down and the skin structure reconstruction is impaired.
- Full text:2026041111531558442脂多糖结合蛋白对小鼠烫伤创面愈合的影响_钟敏.pdf
