The experimental study of titanium nanotube loaded dexamethasone hydroxyapatite composite coating
10.19405/j.cnki.issn1000-1492.2025.08.008
- VernacularTitle:钛纳米管负载地塞米松羟基磷灰石复合涂层的实验研究
- Author:
Qikun Gao
1
;
Mingyue Wu
1
Author Information
1. College & Hospital of Stomatology , Anhui Medical University , Key Lab. of Oral Diseases Research of Anhui Province , Hefei 230032
- Publication Type:Journal Article
- Keywords:
TiO2 nanotubes;
hydroxyapatie;
dexamethasone;
composite coating;
osteoblasts
- From:
Acta Universitatis Medicinalis Anhui
2025;60(8):1418-1422,1431
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the biocompatibility of hydroxyapatite and dexamethasone composite coatings on the surface of TiO2 nanotubes .
Methods:A composite coating was constructed by loading hydroxyapatite and dexamethasone on the surface of titanium nanotubes . Field emission scanning electron microscopy , atomic force microscopy , and contact angle measurement instrument was used to observe the characteristics of sample substrates , and in vitro biological evaluation was conducted to evaluate the effect of the coating on the adhesion and proliferation of human skull osteoblasts .
Results :The microstructure , three_dimensional morphology and hydrophilic properties of the modified composite coating had changed . After cytological examination , it could significantly promote the adhesion and proliferation of osteoblasts .
Conclusion:By simulating the immersion of body fluids and the method of adding dropwise loads , the titanium nanotube_hydroxyapatite_dexamethasone composite coating is successfully constructed , which has good biocompatibility.
- Full text:2026040500010334488钛纳米管负载地塞米松羟基磷灰石复合涂层的实验研究_高啟坤.pdf
