Preliminary exploration of the value of combined detection of folate receptor-positive circulating tumor cells and hemostatic function in improving metastasis diagnosis of gastrointestinal tumor
10.19405/j.cnki.issn1000-1492.2025.09.025
- VernacularTitle:叶酸受体阳性循环肿瘤细胞与止凝血功能联合检测 对提高消化道肿瘤转移诊断的价值初探
- Author:
Yanlin Xiao
1
;
Duxin Ji
2
;
Qingqing Feng
1
;
Huidan He
1
;
Maohong Bian
1
Author Information
1. Dept of Blood Transfusion，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
2. Dept of Neurology，Suzhou Hospital of Anhui Medical University，Suzhou 234000
- Publication Type:Journal Article
- Keywords:
circulating tumor cells;
folate receptor;
gastrointestinal tumors;
liquid biopsy;
hemostatic function;
diagnosis
- From:
Acta Universitatis Medicinalis Anhui
2025;60(9):1755-1761
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the diagnostic value of combined detection of folate receptor-positive circulat- ing tumor cells ( FR + -CTCs) and hemostatic function indicators in improving the diagnosis of gastrointestinal tumors ( GITs) metastasis．
Methods:A retrospective analysis was conducted on the clinical data of 115 patients aged 18 to 80 years who were diagnosed with gastrointestinal tumors via pathology and received treatment，including data on FR + -CTCs，hemostatic function indicators，and pathological staging．The collected data encompassed FR + -CTCs levels，coagulation parameters，and pathological staging．Statistical analysis included t-tests，chi-square tests，fish- er ’s exact test，Logistic regression analysis，and receiver operating characteristic ( ROC) curves to assess the diag- nostic value of combined FR + -CTCs and coagulation parameters in detecting tumor metastasis．
Results:FR + -CTCs levels and positive rates demonstrated significant associations with clinicopathological characteristics ( gender，histo- logical type，N staging) in GITs patients ( P＜0. 05) ．In patients with metastasis，elevated fibrinogen levels were observed．Adithonallly，platelet counts showed significant increases in N1 －N3 stages ( P＜0. 05) ．Logistic regres- sion analysis showed that PLT and antithrombin Ⅲ ( AT-Ⅲ) were independent risk factors for GITs metastasis ( P＜0. 05) ． The areas under the ROC curves for predicting GITs metastasis were 0. 678 ( 95% CI: 0. 540 - 0. 816) and 0. 664 ( 95% CI: 0. 512 －0. 815) ，respectively．When combining multiple factors，including FR + - CTCs，PLT，AT-Ⅲ , pathological type，FIB，TT，and gender，for the diagnosis of GITs metastasis，the AUC in- creased to 0. 757 ( 95% CI: 0. 621 －0. 893) ，indicating higher sensitivity and specificity compared to using each indicator alone．
Conclusion:The combined detection of FR + -CTCs and anticoagulation function indicators has a higher diagnostic value for the diagnosis of GITs，providing a valuable basis for the early diagnosis of GITs，espe- cially in metastasis surveillance．
- Full text:2026032815530047692叶酸受体阳性循环肿瘤细胞与止凝血功能联合检测对提高消化道肿瘤转移诊断的价值初探_肖彦琳.pdf
