Risk factors of symptomatic intracranial hemorrhage after endovascular treatment in patients with acute anterior circulation large vessel occlusion
10.19405/j.cnki.issn1000-1492.2025.09.022
- VernacularTitle:急性前循环大血管闭塞患者 血管内治疗后症状性颅内出血的危险因素分析
- Author:
Ruiling Wang
1
;
Ying Wang
2
;
Min Du
2
;
Rui Tang
2
;
Min Zhou
1
Author Information
1. School of Clinical Medicine，Division of Life Sciences and Medicine，University of Sciences of Technology of China，Hefei 230031; Dept of Critical Care Medicine，The First Affiliated Hospital ( Anhui Provincial Hospital) ，University of Sciences of Technology of China，Hefei 230036
2. Dept of Critical Care Medicine，The First Affiliated Hospital ( Anhui Provincial Hospital) ，University of Sciences of Technology of China，Hefei 230036
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
symptomatic intracranial hemorrhage;
endovascular therapy;
large vessel occlusion;
risk factors;
occlusion location
- From:
Acta Universitatis Medicinalis Anhui
2025;60(9):1730-1734
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the risk factors for symptomatic intracranial hemorrhage ( sICH) after endovascu- lar therapy ( EVT) in patients with acute anterior circulation large vessel occlusion．
Methods:A retrospective a- nalysis was used to analyze the clinical data of 273 anterior circulation large vessel occlusion ( ACLVO) patients with EVT，of which 158 were male and 115 were female; ages ranged from 33 to 94 years old［71 ( 59，78) years old］，and sICH occurred in 61 cases．The patients' gender，age，history of smoking and alcohol consumption，his- tory of illness，history of oral anticoagulant / anti-antibiotic administration，oral anticoagulant / antiplatelet medication status，intravenous thrombolytic therapy，admission blood pressure，hospitalization days，occlusion location，proce- dure duration，number of times of thrombus retrieval，cause of stroke ( TOAST classification) ，revascularization status ( mTICI ≥2b) ，and admission ASPECT score，admission APACHEII score，and admission NHISS score were collected．Univariate analysis was used to compare the differences in the above indicators between the non- SICH group and the sICH group． Multivariable Logistic regression analysis was used to evaluate the independent factors for the occurrence of sICH after EVT．
Results:The results of univariate analysis showed that mTICI ≥ 2b， admission ASPECT score，and post-EVT sICH were significantly negatively correlated ( P＜0. 05) ，while occlusion location ( ICA) ，admission APACHE-Ⅱ score，admission NHISS score＞20，and admission mRS score were sig- nificantly positively correlated with post-EVT sICH ( P＜0. 05) ．The results of the multivariable Logistic regression analysis indicated that mTICI≥2b ( OR = 0. 314，95% CI: 0. 106－0. 929) and admission ASPECT score ( OR = 0. 775，95% CI: 0. 604－0. 995) are protective factors for sICH after EVT，while occlusion location ( ICA) ( OR = 2. 047，95% CI: 1. 033－4. 054) and admission APACHE-Ⅱ score ( OR = 1. 236，95% CI: 1. 140 －1. 340) were risk factors for sICH after EVT．
Conclusion:Higher admission APACHEII score，lower admission ASPECT score，occlusion location ( ICA) ，and mTICI ＜2b are independent risk factors for the development of sICH after EVT in patients with acute ACLVO．
- Full text:2026032815293452883急性前循环大血管闭塞患者血管内治疗后症状性颅内出血的危险因素分析_王睿玲.pdf
