Status of high-risk HPV infection and its relationship with vaginal infectious diseases
10.19405/j.cnki.issn1000-1492.2025.09.020
- VernacularTitle:高危型 HPV 感染现况及其与阴道感染性疾病的关系
- Author:
Maochao Bai
1
;
Yan Wang
2
;
Fanka Li
3
;
Hua Wang
4
;
Yan Guo
1
;
Hui Zhang
5
Author Information
1. School of Public Health，Xinjiang Medical University，Urumqi 830011
2. Office of Tumor Prevention and Research，XinjianMedical University Cancer Hospital，Urumqi 830011;
3. Disease Prevention and Control Bureau of Xinjiang Production and Construction Corps，Urumqi 830011
4. Dept of Public Health，Fourth Division Hospital，Xinjiang Production and Construction Corps，Kokdara 835000
5. Dept of Maternal and Child Health，Center for Disease Control and Prevention，Xinjiang Production and Construction Corps，Urumqi 830011
- Publication Type:Journal Article
- Keywords:
human papillomavirus;
high-risk type;
age;
prevalence;
type of infection;
vaginal infectious diseases
- From:
Acta Universitatis Medicinalis Anhui
2025;60(9):1719-1724
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the high-risk human papillomavirus ( HR-HPV) infection and its relationship with vaginal infectious diseases among women and to provide a basis for the prevention and control of cervical canc- er among women in this region．
Methods:Uterine exfoliative cells and vaginal secretions were collected from women aged 25－64 years in the resident population ( ≥6 months of residence) who participated in cervical cancer screening and human papillomavirus typing and vaginal microecology tests were performed to compare the status of HPV infections in different age groups．The study subjects were divided into HR-HPV-positive and HR-HPV-nega- tive groups according to whether HR-HPV infection was detected or not，and multifactorial Logistic regression anal- ysis was used to explore the relationship between HR-HPV and vaginal infectious diseases．
Results :The HR-HPV infection rate of women in this study was 10. 43% ，and the HR-HPV infection rate of each age group was 14. 34% from 25 to 34 years old，10. 16% from 35 to 44 years old，8. 70% from 45 to 54 years old，and 11. 89% from 55 to 64 years old，and there were differences in the infection rate of HR-HPV among different age groups ( P < 0. 05) ．Among HR-HPV，HPV52，HPV16，HPV58，HPV51，HPV68 were the most common，with 76. 69% of sin- gle infections，18. 02% of dual infections，4. 46% of triple infections，and 0. 83% of quadruple infections．HR- HPV single infections and multiple infections were prevalent in the age group of 25－34 years old and 55－64 years old．HR-HPV mono-infection and multi-infection rates were statistically different between age groups ( P＜0. 05) ． The infection rates of bacterial vaginosis ( BV) and trichomoniasis vaginitis ( TV) were higher in HR-HPV-positive patients ( P ＜0. 05) ． Logistic regression analysis showed that the infection rates of BV ( OR = 1. 560，95% CI: 1. 195－2. 035 ) ，TV ( OR = 2. 208，95% CI: 1. 221 －3. 993 ) were risk factors for HR-HPV infection ( P < 0. 05) ．
Conclusion:In the screened population of the Fourth Division of Xinjiang Production and Construction Corps，HR-HPV mono-infection is the most prevalent type．Women aged 25－34 and 55－64 years old show higher rates of HR-HPV infection．The most common HR-HPV genotypes，in descending order，are 52，16，58，51，and 68．BV and TV are the two major risk factors closely associated with HR-HPV infection．
- Full text:2026032814411572995高危型HPV感染现况及其与阴道感染性疾病的关系_白茂潮.pdf
