Causal relationship between intestinal flora and esophageal cancer: A Mendelian randomization analysis
- VernacularTitle:基于孟德尔随机化分析肠道菌群与食管癌的因果关系
- Author:
Mengmeng WANG
1
;
Mingjun GAO
1
;
Siding ZHOU
2
;
Shuyu TIAN
1
;
Yusheng SHU
3
;
Xiaolin WANG
3
Author Information
1. Clinical Medical College, Dalian Medical University, Dalian, 116000, Liaoning, P. R. China
2. Clinical Medical College, Yangzhou University, Yangzhou, 225000, Jiangsu, P. R. China
3. Department of Thoracic Surgery, Northern Jiangsu People's Hospital, Yangzhou, 225000, Jiangsu, P. R. China
- Publication Type:Journal Article
- Keywords:
Esophageal cancer;
intestinal flora;
causal association;
Mendelian randomization;
inverse variance weighted;
Genome-wide Association Studies;
single-nucleotide polymorphism;
instrumental variables
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(03):397-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether there is a causal relationship between intestinal flora and esophageal cancer. Methods Summary statistics of intestinal flora and esophageal cancer were obtained from the Genome-wide Association Studies (GWAS) database. Five methods, including inverse variance weighted (IVW), weighted median estimation, Mendelian randomization (MR)-Egger regression, single mode, and weighted mode, were used for analysis, with IVW as the main analysis method. Sensitivity analysis was used to evaluate the reliability of MR results. Results In the IVW method, Oxalobacteraceae [OR=1.001, 95%CI (1.000, 1.002), P=0.023], Faecalibacterium [OR=1.001, 95%CI (1.000, 1.002), P=0.028], Senegalimassilia [OR=1.002, 95%CI (1.000, 1.003), P=0.006] and Veillonella [OR=1.001, 95%CI (1.000, 1.002), P=0.018] were positively correlated with esophageal cancer, while Burkholderiales [OR=0.999, 95%CI (0.998, 1.000), P=0.002], Eubacterium oxidoreducens [OR=0.998, 95%CI (0.997, 0.999), P=0.038], Romboutsia [OR=0.999, 95%CI (0.998, 1.000), P=0.048] and Turicibacter [OR=0.998, 95%CI (0.997, 0.999), P=0.013] were negatively correlated with esophageal cancer. Sensitivity analysis showed no evidence of heterogeneity, horizontal pleiotropy and reverse causality. Conclusion Oxalobacteraceae, Faecalibacterium, Senegalimassilia and Veillonella increase the risk of esophageal cancer, while Burkholderiales, Eubacterium oxidoreducens, Romboutsia and Turicibacter decrease the risk of esophageal cancer. Further studies are needed to explore how these bacteria affect the progression of esophageal cancer.
