Research progress and prospect of molecular mechanism, biomarkers and treatment of bone metastasis in lung cancer
- VernacularTitle:肺癌骨转移的分子机制、生物标志物及治疗研究进展
- Author:
Pengfei ZHOU
1
;
Jie ZHOU
2
;
Hongwei ZHANG
1
Author Information
1. Department of Thoracic Oncology, Meishan Cancer Hospital, Meishan, 620020, Sichuan, P. R. China
2. Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, 610041, P. R. China
- Publication Type:Journal Article
- Keywords:
Lung cancer;
bone metastasis;
biomarkers;
molecular mechanism;
treatment;
surgery;
radiotherapy and chemotherapy treatment;
targeted therapy;
immunotherapy
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(02):311-317
- CountryChina
- Language:Chinese
-
Abstract:
Bone metastasis is one of the common complications of lung cancer, which seriously affects the quality of life and survival of patients. At present, the clinical diagnosis of bone metastasis of lung cancer mainly depends on imaging methods, but due to its lack of sensitivity and potential radiation risk, about half of patients have already had bone-related events when they are diagnosed clearly. The treatment of bone metastasis of lung cancer mainly depends on surgery, radiotherapy and chemotherapy, targeted therapy, immunotherapy, etc. Although the treatment of bone metastasis of lung cancer has made some progress in recent years, there are still some problems such as high risk of other distant metastasis. This article mainly reviews the pathogenesis, diagnostic biomarkers and treatment progress of bone metastasis of lung cancer, in order to provide reference for the diagnosis and treatment of bone metastasis of lung cancer.
