Risk factors associated with lymph node metastasis in lung adenocarcinoma with a diameter≤3 cm
- VernacularTitle:直径≤3 cm肺腺癌淋巴结转移危险因素分析
- Author:
Shaowei XIN
1
,
2
,
3
;
Xiangbing XIN
1
;
Yabo ZHAO
1
;
Miaomiao WEN
1
;
Suxin JIANG
2
;
Yanlu XIONG
1
,
4
Author Information
1. Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, P. R. China
2. Department of Thoracic Surgery, Air Force Medical Center, Air Force Medical University, Beijing, 100142, P. R. China
3. Department of Thoracic Surgery, 962 Hospital of Joint Logistics Support Force, Harbin, 150000, P. R. China
4. Innovation Center for Advanced Medicine, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, P. R. China
- Publication Type:Journal Article
- Keywords:
Lung adenocarcinoma;
early-stage lung cancer;
lymph node metastasis;
micropapillary component;
solid component;
vascular invasion;
pleural invasion;
risk factor analysis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(02):255-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between lymph node metastasis and clinicopathological features of lung adenocarcinoma with diameter≤3 cm. Methods The clinicopathologic data of the patients with lung adenocarcinoma≤3 cm in diameter were retrospectively analyzed. The relationship between lymph node metastasis and age, gender, smoking history, pathological subtype, tumor diameter, pleural invasion, vascular invasion and other factors was analyzed. The risk factors of lymph node metastasis were analyzed by univariate and multivariate logistic regression. Results Finally 1 718 patients were collected, including 697 males and 1 021 females with an average age of (58.89±9.85) years. The total lymph node metastasis rate was 12.9%, among whom 452 patients of adenocarcinoma in situ and minimally invasive adenocarcinoma did not have lymph node metastasis, and the lymph node metastasis rate of invasive lung adenocarcinoma was 17.5%. Multivariate analysis showed that tumor diameter, micropapillary subtype, solid subtype, micropapillary component, solid component, vascular invasion and pleural invasion were independent risk factors for lymph node metastasis of invasive lung adenocarcinoma with diameter≤3 cm (P<0.05). While age, lepidic subtype and lepidic component were independent protective factors for lymph node metastasis (P<0.05). Conclusion Clinicopathological features can help predict lymph node metastasis of lung adenocarcinoma with diameter≤3 cm.
