Study on the role of oleuropein in enhancing muscle endurance
10.12206/j.issn.2097-2024.202510011
- VernacularTitle:橄榄苦苷在肌肉耐力提升中的作用研究
- Author:
Huan LI
1
;
Zhen ZHANG
2
;
Jiayi FENG
1
;
Weidong ZHANG
1
;
Xia LIU
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China;Department of Gastroenterology, Navy No. 971 Hospital, Qingdao 266000, China.
- Publication Type:Originalarticles
- Keywords:
oleuropein;
muscle fatigue;
orosomucoid1（ORM1）;
glycogen;
muscle endurance
- From:
Journal of Pharmaceutical Practice and Service
2026;44(3):126-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective Orosomucoid1 （ORM1） is a novel target in the quest for anti-fatigue pharmacotherapy. Preliminary investigations have illuminated oleuropein （OLE） as a promising candidate molecule, poised to enhance ORM1 expression. To elucidate the influence of OLE on ORM1 protein expression and assess its ramifications on muscle endurance. Methods The impact of OLE on ORM1 protein expressions within hepatocytes and liver tissue was meticulously quantified through Western blotting; the effects of OLE on muscle endurance were evaluated via the rotarod and forced swimming tests; glycogen content within liver and muscle tissues was determined utilizing a specialized kit; and PAS staining was employed to visualize glycogen deposition in the gastrocnemius muscle. Results OLE demonstrated a capacity to elevate ORM1 protein expression in hepatocytes in a time- and dose-dependent manner, concurrently prolonging the duration of swimming and rotarod performance in mice, also in a time- and dose-dependent manner. Furthermore, OLE augmented ORM1 expression in liver tissue, elevated serum ORM1 levels, and enhanced glycogen reserves within the liver and muscle. Conclusion OLE may serve to amplify muscle endurance by elevating ORM1 levels in vivo and augmenting glycogen stores within skeletal muscle.
