Progress on Chinese medicine compound formulae in modulating relevant signaling pathways for the treatment of simple obesity
10.12206/j.issn.2097-2024.202505004
- VernacularTitle:中药复方调控相关信号通路治疗单纯性肥胖的研究进展
- Author:
Xiali ZHANG
1
;
Zhuo WANG
2
;
Li MI
3
Author Information
1. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China;Department of Pharmacy, Armed Police Force Shanghai General Hospital, Shanghai 201103, China.
2. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
3. Department of Pharmacy, Armed Police Force Shanghai General Hospital, Shanghai 201103, China.
- Publication Type:Reviews
- Keywords:
simple obesity;
Chinese medicine compounding;
signaling pathway;
MAPK
- From:
Journal of Pharmaceutical Practice and Service
2026;44(3):120-125
- CountryChina
- Language:Chinese
-
Abstract:
Obesity has become a major global health challenge. The treatment of simple obesity patients with Chinese medicine compound based on evidence-based therapy has the advantages of good clinical efficacy and high safety. Chinese medicine compound can play the role of reducing inflammation, improving oxidative stress and regulating insulin resistance by regulating MAPK, AMPK, JAK/STAT, PI3K-Akt-mTOR, NF-κB, PPARγ/RXRα, STING-IRF3 and other related signaling pathways, which is characteristic of multi-component, multi-pathway, multi-target regulation. The research progress in the modulation of relevant signaling pathways by traditional Chinese medicine combinations for the treatment of simple obesity were reviewed, which provided a theoretical basis and research ideas for clinical practice.
