Application of Raman spectroscopy in the quality control and in vitro permeation studies of topical drug formulations
10.12206/j.issn.2097-2024.202409017
- VernacularTitle:拉曼光谱在皮肤外用制剂质量与体外透皮研究中的应用
- Author:
Yingxin CUI
1
;
Jingjing WEI
2
;
Xiaoxia YE
3
;
Jian LE
3
Author Information
1. School of Pharmacy, Fudan University, Shanghai 201203, China;Shanghai Institute of Food and Drug Control, Shanghai 201203, China;Key Laboratory for Quality Analysis of Chemical Drug Preparations, National Medical Products Administration, Shanghai 201203, China.
2. China National Institute for Food and Drug Control, Beijing 102629, China.
3. Shanghai Institute of Food and Drug Control, Shanghai 201203, China;Key Laboratory for Quality Analysis of Chemical Drug Preparations, National Medical Products Administration, Shanghai 201203, China.
- Publication Type:Reviews
- Keywords:
topical formulations;
Raman spectroscopy;
quality study;
skin
- From:
Journal of Pharmaceutical Practice and Service
2026;44(3):113-119
- CountryChina
- Language:Chinese
-
Abstract:
Transdermal drug delivery offers advantages such as safety, convenience, and high patient compliance. However, the complex structure of the skin and significant individual variability, particularly the barrier function of the stratum corneum, result in generally low bioavailability for topical formulations. The formulation of topical drug products is complex, with numerous factors influencing quality, which requires strict control of product quality. Raman spectroscopy, as a non-destructive vibrational technique, combined with chemometric methods, imaging technology, and other spectroscopic techniques, can be applied to study the key quality attributes of topical drug formulations. The applications of Raman spectroscopy in studies of the crystal form, particle size distribution, excipient research, and in vitro transdermal experiments of topical drug formulations were summarized. In particular, it focused on the use of Raman spectroscopy in the selection of skin samples for in vitro permeation tests, the study of drug spatial distribution in the skin, and the interactions between drugs and the skin.
