Treatment of Colorectal Cancer with Traditional Chinese Medicine Based on Hippo Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20251326
- VernacularTitle:基于Hippo信号通路探讨中医药治疗结直肠癌的研究进展
- Author:
Shuo ZENG
1
;
Suqin HU
2
;
Yang HU
1
;
Lei LUO
2
;
Mingyan LI
2
;
Qinsheng ZHANG
2
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046，China
2. The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
Hippo signaling pathway;
traditional Chinese medicine;
colorectal cancer;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(8):297-305
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer， a leading malignant gastrointestinal tumor globally in terms of incidence and mortality， has seen a consistent annual rise in newly diagnosed cases. While conventional therapies like radiotherapy， chemotherapy， and surgery are available， problems such as lack of early diagnosis， poor prognosis， and drug resistance remain significant burdens for patients. Given the complex and diverse pathogenesis of colorectal cancer， there is an urgent clinical need for safe， effective， reliable， and multi-targeted therapeutic strategies. The Hippo signaling pathway， closely linked to mechanisms like tumorigenesis， cancer cell invasion， migration， and drug resistance， extensively participates in the occurrence and development of colorectal cancer， so targeting the signaling pathway for cancer prevention and treatment has become a crucial research direction in recent years. Traditional Chinese medicine （TCM） offers multi-faceted， multi-pathway， and multi-target advantages and becomes an important therapy for colorectal cancer by enhancing patients' immunity， improving the life quality， and prolonging survival. Studies show that the active components of TCM， including flavonoids， terpenoids， phenols， alkaloids， quinones， lignans， and saponins， as well as TCM compounds such as modified Sijunzi decoction， Jiedu Sangen decoction， Jianpi Jiedu compound， and Quyu Jiedu decoction， exhibit significant targeting effects on the Hippo signaling pathway. These TCMs can exert an anti-colorectal cancer effect through various mechanisms， such as inducing cancer cell autophagy and apoptosis， inhibiting epithelial-mesenchymal transition， reversing drug resistance of the tumor， and blocking the cancer cell cycle. This paper reviewed and analyzed Chinese and international research on the action mechanisms of TCM in regulating the Hippo signaling pathway for the prevention and treatment of colorectal cancer with a comprehensive overview presentation， aiming to provide new references and ideas for the clinical application of TCM and the development of new pharmacological agents in the prevention and treatment of colorectal cancer.
