Research progress of luteolin in ocular diseases
10.3980/j.issn.1672-5123.2026.4.17
- VernacularTitle:木犀草素在眼科疾病中的研究进展
- Author:
Sijie HE
1
;
Bin GUO
1
;
Wenjun JIANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
luteolin;
ocular diseases;
antioxidation;
anti-inflammation
- From:
International Eye Science
2026;26(4):651-656
- CountryChina
- Language:Chinese
-
Abstract:
Natural flavonoids have attracted considerable attention owing to their favorable biosafety profiles and multiple pharmacological properties in recent years. Luteolin, a representative flavonoid compound, exhibits anti-inflammatory, antioxidant, anti-angiogenic, and neuroprotective effects in multiple ocular disease models by modulating key signaling pathways, including NF-κB, PI3K/Akt, Nrf2/HO-1, and AGE-RAGE. Accumulating experimental evidence supports the potential application of luteolin in various ocular diseases, including corneal and ocular surface diseases, inflammatory eye diseases, glaucoma, cataract, diabetic retinopathy, and age-related macular degeneration. However, clinical evidence remains limited. This review systematically summarizes research progress on luteolin in ocular diseases over the past five years, analyzes its molecular mechanisms and therapeutic potential, and discusses future directions,so as toprovide a theoretical basis for clinical translation.
