Research progress on the comorbidity mechanism of dry eye and depression
10.3980/j.issn.1672-5123.2026.4.13
- VernacularTitle:干眼与抑郁共病机制的研究进展
- Author:
Yunfan ZHANG
1
;
Kang WANG
1
;
Jing LI
1
Author Information
1. Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100040, China; Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Journal Article
- Keywords:
dry eye;
depression;
comorbidity mechanism
- From:
International Eye Science
2026;26(4):629-635
- CountryChina
- Language:Chinese
-
Abstract:
Dry eye disease(DED)and depression(DEP), though anatomically and clinically distinct, show significant epidemiological, pathophysiological, and prognostic interplay. Their co-occurrence has risen sharply in recent years, yet the mechanisms driving this comorbidity remain under-investigated. This review systematically synthesizes current evidence, highlighting that pro-inflammatory cytokines, neuro-regulatory imbalance, mitochondrial dysfunction, and gut-microbiota dysbiosis constitute a shared molecular network, while sleep deprivation and antidepressant use further amplify the vicious cycle. By identifying limitations in existing studies, this review proposes future research directions to offer new theoretical and clinical insights for managing DED-DEP comorbidity.
