Research progress on the application of multi-omics in the pathogenesis of dry eye
10.3980/j.issn.1672-5123.2026.4.09
- VernacularTitle:多组学在干眼发病机制中的应用研究进展
- Author:
Feng WANG
1
;
Yi SHAO
1
;
Tingting LIU
1
;
Jiangfeng LAI
1
Author Information
1. Department of Ophthalmology, Meizhou Pepole's Hospital, Meizhou 514000, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
dry eye disease;
multi-omics;
metabolomics;
biomarker
- From:
International Eye Science
2026;26(4):605-610
- CountryChina
- Language:Chinese
-
Abstract:
Dry eye disease(DED)is a multifactorial disorder with an unclear pathogenesis. Advances in omics technologies have introduced a novel medical research approach, enabling the identification of global response variables from a single-factor perspective. However, multi-omics methods integrate multiple omics datasets to analyze all potential response variables, generating multidimensional and evidence-supported holistic inferences. These insights help elucidate functional impairments of ocular cells and biomolecular processes during disease progression, thereby revealing correlations between biomolecules and complex diseases. This review summarizes the application of multi-omics technologies in clarifying the pathogenesis and intricate molecular mechanisms of dry eye disease. Distinctive features from genomics, transcriptomics, proteomics, metabolomics, and microbiomics are integrated to deepen the understanding of the pathogenesis and complex molecular mechanisms underlying dry eye disease.
